Author/Editor     Veranič, P; Jezernik, K
Title     Succession of events in desquamation of superficial urothelial cells as a response to stress induced by prolonged constant illumination
Type     članek
Source     Tissue Cell
Vol. and No.     Letnik 33, št. 3
Publication year     2001
Volume     str. 280-5
Language     eng
Abstract     The effect of moderate stress induced by prolonged illumination was analysed on urothelial cells of female mouse urinary bladders at ultrastructural and cytochemical levels. This study demonstrates that the urothelium responds to moderate stress with desquamation which involves two subsequent steps. The first step includes a local detachment of tight junctions and consequently the loss of the permeability barrier leading to expanded intercellular spaces among urothelial cells. During the second step, the disjunction of desmosomes accompanied by exocytosis of lysosomal enzymes (NADPase) in the intercellular space results in exfoliation of superficial cells. It is evident that moderate stress elicits an enhanced desquamation of only superficial cells by a subsequent dysfunction of first tight junctions and after that adherens-type junctions. A rapid restoration of the new tight junctions prevents a long-term malfunction of the blood-urine barrier.
Descriptors     BLADDER
UROTHELIUM
STRESS
LIGHTING
TIGHT JUNCTIONS
MICE
DESMOSOMES
MICROSCOPY, ELECTRON
NAD+ NUCLEOSIDASE
EXOCYTOSIS