Author/Editor		Hočevar, Stanko; Žmitek, Janko; Kocjan, Darko; Levec, Janez
Title		Kinetične raziskave kot osnova za študij mehanizmov in optimizacijo sinteze učinkovin - primer pretvorb tritilamilodipina
Type		članek
Source		In: Glavič P, Brodnjak-Vončina D, editors. Zbornik referatov s posvetovanja Slovenski kemijski dnevi 2001: 1. del; 2001 sep 20-21; Maribor. Maribor: Univerza v Mariboru, Fakulteta za kemijo in kemijsko tehnologijo,
Publication year		2001
Volume		str. 270-5
Language		slo
Abstract		Kinetics investigations of trityl-amlodipine transformation into amlodipine benzenesulfonate are presented as a basis for reaction mechanism investigation and process optimisation. In this case C-N bond cleavage was found to proceed with amlodipine salt elimination. Interactions of the dihydropyridine part of the molecule were observed to interact as well, yielding some of the by-products. Optimal reaction conditions for the synthesis of amlodipine benzenesulfonate have been elaborated.
Descriptors		AMLODIPINE KINETICS TRITYL COMPOUNDS ALCOHOL, METHYL CHLOROFORM