Author/Editor		Pompe-Novak, Maruša; Ravnikar, Maja; Žerovnik, Eva
Title		Neural inclusions in the light of new findings on protein fibrilization
Type		članek
Source		In: Vodušek DB, Repovš G, editors. Informacijska družba IS'01. Kognitivna nevroznanost IS'01. Zbornik B 4. mednarodne multi-konference; 2001 okt 22-26; Ljubljana. Ljubljana: Inštitut Jožef Stefan,
Publication year		2001
Volume		str. 72-5
Language		eng
Abstract		It has been shown that nearly all neurodegenerative diseases from the group of TSE to poli-glutamine repeat disorders and Alzheimers disease show cellular, endosome/lysosome or nuclear inclusions. These result from aberrant folding (conformational change) of various proteins leading to ordered aggregates known under the name of "fibrils" (two-chain), "protofilaments" (one-chain) and pre-fibrillar oligomers or "protofibrils". A short review of the common findings in the field of protein fibrillization and its connection to the "conformational" diseases is given. Highlighted is an example of human stefin B (cystatin B), a cysteine proteinase inhibitor, which readily forms fibrils in vitro.
Descriptors		CYSTATINS PROTEIN CONFORMATION NEUROFIBRILS NEUROFIBRILLARY TANGLES NERVOUS SYSTEM DISEASES INCLUSION BODIES