Author/Editor		Grad, Anton
Title		Vpliv sladkorne bolezni na možganskožilne bolezni
Translated title		The impact of diabetes mellitus on cerebrovascular disorders
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 40, št. Suppl 3
Publication year		2001
Volume		str. 45-8
Language		slo
Abstract		Epidemiological studies show that diabetes is a risk factor for ischemic stroke. The pathogenesis of diabetes associated stroke appears to be linked to excessive glication and oxidation, endothelial dysfunction, increased platelet aggregation, impaired fibrinolysis and insulin resistance. These disorders result in cerebral small artery occlusions and lacunar infarctions. On the other hand diabetics are prone to large artery atherosclerotic changes of intima. Tight glycemic control, treatment of dyslipedemia and other primary prevention measures are recommended.
Summary		Epidemiološke raziskave kažejo, da je sladkorna bolezen pomemben dejavnik tveganja za možganskožilne bolezni. Natanek bolezni je posledica glikacije in oksidacije, zadebelitve endotelija, pospešene agregacije trambocitov, motnje fibrinolize in neodzivnosti na inzulin. Te motnje vodijo do zapore malih arterije in lakunarnih infarktov. Na drugi strani pa so bolniki s sladkorno boleznijo nagnjeni k aterosklerotičnim spremembam intime velikih arterij. Priporočamo energično kontrolo vrednosti krvnega sladkorja, energično zdravljenje motene presnove maščob in upoštevanje drugih ukrepov primarne preventive.
Descriptors		DIABETES MELLITUS CEREBROVASCULAR DISORDERS