Author/Editor		Žvan, Bojana; Zaletel, Marjan
Title		Motnje možganske avtoregulacije pri bolnikih s sladkorno boleznijo
Translated title		Disfunction of the cerebral autoregulation in diabetic patients
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 40, št. Suppl 3
Publication year		2001
Volume		str. 157-62
Language		slo
Abstract		Patients with diabetes mellitus have a damage of the sympathetic nerves which innervate cranial base arteries. Therefore, these patients have disturbed regulation of the blood flow in the middle cerebral arteries. It has been found that during cold pressor test stimulation the constriction potential in groups of diabetics with autonomous neuropathy is significantly lower than in healthy population. Therefore, it can be concluded that diabetics have less efficient cerebrovascular reactivity and thus also a narrower area of effective cerebral autoregulation activity. This fact may contribute to an increased risk of cerebral ischemia.
Summary		Bolniki s sladkorno boleznijo imajo okvaro simpatičnega živčevja, ki oživčuje arterije na lobanjski bazi. Zato imajo ti bolniki moteno uravnavanje krvnega pretoka v srednjih možganskih arterijah. Med sistemsko stimulacijo simpatičnega živčevja s testom omočitve roke v ledeno vodo je sposobnost konstrikcije pri skupinah bohiikov s sladkorno boleznijo z avtonomno nevropatijo pomembno manjša kot pri zdravih osebah. Bolniki s sladkorno boleznijo imajo slabšo možganskožilno odzivnost in s tem ožje območje uspešnega delovanja mehanizmov možganske avtoregulacije. Verjetno je, da to dejstvo zveča tveganje za razvoj možganske ishemije.
Descriptors		DIABETES MELLITUS CEREBROVASCULAR CIRCULATION SYMPATHETIC NERVOUS SYSTEM TILT-TABLE TEST ULTRASONOGRAPHY, DOPPLER, TRANSCRANIAL ELECTROCARDIOGRAPHY CAPNOGRAPHY BLOOD FLOW VELOCITY