Author/Editor		Skok, Pavel
Title		Vpliv izkoreninjenja bakterije Helicobacter pylori na razvoj refluksne bolezni požiralnika pri bolnikih s krvavečo peptično razjedo
Translated title		The influence of helicobacter pylori eradication on development of reflux disease of the esophagus in patients with bleeding peptic ulcer
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		2001
Volume		str. 115
Language		slo
Abstract		Introduction Peptic ulcer disease belongs among the most frequent diseases of man as epidemiologists judge that every tenth adult contracts this disease once in his lifetime. The explanation of peptic ulcer etiology has changed significantly in the past decade after the clarification of the significance of Helicobacter pylori infection. Treatment of the infection lead to a decrease in the number of ulcer disease recurrences, however, during this period epidemiologists established an increase in the incidence of gastroesophageal reflux disease among inhabitants of the developed world. A possible association of GERD with peptic ulcer, HP infection or the results of eradication of the infection has not been elucidated. It is an alarming fact that in developed countries the incidence of esophageal adenocarcinoma; which is associated with GERD, is increasing The aim of the study was to establish the prevalence of esophageal reffux disease and the manifestation lof changes of the esophageal mucosa after eradication of HP infection in patients with hemorrhaging peptic ulcer of stomach or duodenum and patients with peptic ulcer without complications. Study ethics The study was approved in 1998 by the Medical Ethics Committee of the Republic of Slovenia (No.90/a9/98). Prior to inclusion in the study all patients were acquainted with the aims of the study and their participation was voluntary. The study was carried out in accordance with the principles of the Helsinki - Tokyo Declaration and the Code of Ethics of Slovene health workers. Type of study The prospective, controlled and randomized study was carried out between 1998 and 2000. (Abstract truncated at 2000 characters)
Descriptors		HELICOBACTER PYLORI HELICOBACTER INFECTIONS GASTROESOPHAGEAL REFLUX PEPTIC ULCER HEMORRHAGE SCLEROTHERAPY GASTRITIS TREATMENT OUTCOME HYDROGEN-ION CONCENTRATION ESOPHAGUS BARRETT ESOPHAGUS BILIRUBIN