Author/Editor     Galli, M
Title     Antiphospholipid antibodies: predictive value of laboratory tests
Type     članek
Source     In: Pathophysiological, clinical and laboratory aspects of thromboembolic disease. Proceedings of the 8th advanced teaching course in thrombosis and haemostasis; 2001 Mar 22-27; Kranjska gora. Ljubljana: University medical center, Department of angiology,
Publication year     2001
Volume     str. 40-4
Language     eng
Abstract     The results of an analysis of studies published over a 10-year period that addressed the association between antiphospholipid (aPL) antibodies and thromboembolic events in patients with the antiphospholipid syndrome (APS) are reported. It would appear that lupus anticoagulants are the strongest risk factor for thromboembolic events in aPL-positive patients. Consequently, it is suggested that all patients with clinical manifestations of APS should be tested for these antibodies. On the other hand, the results do not unequivocally show that measurement of anticardiolipin antibodies is of help in defining the thrombotic risk of patients. Furthermore, they only partially support the notion that anti-beta2-glycoprotein I and antiprothrombin antibodies may be independent risk factors for thrombosis.
Descriptors     THROMBOEMBOLISM
ANTIPHOSPHOLIPID SYNDROME
ANTIBODIES, ANTIPHOSPHOLIPID
ANTIBODIES, ANTICARDIOLIPIN