Author/Editor		Pišljar, Marko; Denišlič, Miro; Meh, Duška
Title		Ocena vala P300 pri bolnikih s Parkinsovo boleznijo
Translated title		P300 wave confirmation in patients with Parkinson's disease
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 70, št. 11
Publication year		2001
Volume		str. 647-50
Language		slo
Abstract		Background. Mild to moderate cognitive dysfunction is a frequent complaint of patients with Parkinson's disease, though the clinical picture of dementia is rarely reported. Methods. The development of cognitive deficits seams to be associated with hypokinesia and rigidy rather than tremor. In our study, auditory ERP were used to confirm cognitive alterations in two groups of non-dementedpatients with idiopathic Parkinson's disease. Mini mental test was performed to exclude clinical picture of dementia. Patients were classified according to the Hoehen-Yahr and Webster scale. The Beck depression score in Parkinson's patient was assessed. Auditory event related potentials were recorded using the "oddball" paradigm. The waves N100, P200, N200 and P300 were recorded and their latencies and amplitudes measured Results and conclusions. The P300 latencies in both patients group were significantly longer (p < 0.05), than in the control group. P300 latency was longer in non tremor group. There were no significant statistical differences in latencies between the both groups. All patients had normal N100 latency. Significant decline of P300 amplitude was found only in non-tremor group (p < 0.001).
Summary		Izhodišča. Bolniki s Parkinsonovo boleznijo (PB) se pogosto pritožujejo nad blagimi in zmernimi motnjami spoznavnih sposobnosti, kliničnih znakov demence pa običajno ne najdemo. Motnje spoznavnih sposobnosti so pogosteje kot s tresenjem povezane s hipokinezo in z rigidnostjo. Metode. V naši raziskavi smo za oceno kognitivnih sprememb pri dveh skupinah bodnikov s Parkinsonovo boleznijo uporabili akustične pozne izvabljene odzive (event related potentials - ERP). Bolnike smo klasificirali v skladu z Hoehen-Yahrovo in Webstrovo lestvico. Vsi preiskovanci so opravili kratek preizkus spoznavnih sposobnosti zaradi izključitve klinične slike demence ter Beckovo lestvico depresivnosti. Pozno izvabljene odzive smo zbirali ob uporabi klasične "oddball" paradigme. Merili smo latenco in amplitudo valov N100, P200, N200 in P300. Rezultati in zaključki. V raziskavi smo pri obeh skupinah bolnikov izmerili značilno daljše latence vala P300 (p < 0,05) kot v kontrolni skupini. Latenca vala P300 je bila daljša v skupini netresočih se bolnikov. Med obema skupinama bolnikov nismo našli statistično značilnih razlik. Vsi bolniki so imeli normalno latenco vala N100. Statistično značilno manjšo amplitudo P300 smo našli le pri skupini netresočih se bolnikov (p < 0, 001).
Descriptors		PARKINSON DISEASE EVENT-RELATED POTENTIALS, P300 COGNITION DISORDERS