Author/Editor		Fikfak, Nataša; Frković-Grazio, Snježana
Title		Sekundarni angiotropni velikocelični limfom in diseminirani plazmocitom - prikaz primera
Translated title		Secondary angiotropic large cell lymphoma in patient with multiple myeloma - a case report
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 70, št. 11
Publication year		2001
Volume		str. 683-6
Language		slo
Abstract		Background. Seventy years old man presents with low back pain, elevated eritrocite sedimentation rate, normocitic anemia and elevated concentration of serum creatinine. A diagnosis of multiple myeloma Ig G lambda was made. After five cycles of chemotherapy he reached complete haematologic remission and clinic well-being. After a month he complains of new troubles, pains primarily of non-haematopoetic organs involvement. With histologic examinations of target organs amyloidosis was excluded, there were found elements of infiltration with angiotropic Non Hodgkin B-cell lymphoma. Conclusion. In patient with multiple myeloma in haematologic remission and new symptoms and signs of primarily involvement of non-haematopoetic organs we first think about amydoidosis. Rarely but, there is a case, of second lymphoproliferative disease.
Summary		Izhodišča 70-letnemu bolniku z bolečinami v hrbtenici, pospešeno hitrostjo sedimentacije eritrocitov, normocitno anemijo in zvečano koncentracijo kreatinina smo ugotavili diseminirani plazmocitom Ig G lambda. Po petih krogih zdravljenja je bila dosežena hematološka remisija in izboljšanje kliničnega stanja. Mesec dni kasneje pa so se pojavile nove težave, ki so bile posledica prizadetosti nehematopoetičnih organov (jetra, vranica, endokrine žleze). Amiloidoza je bila izključena s histološko preiskavo prizadetih organov, potrdila pa je angiotropni Nehodgkinov B-celični limfom. Zaključki. Pri pojavu novih težav, ki so posledica prizadetosti nehematopoetskih organov, najprej pomislimo na amiloidozo, redkeje pa na druge limfoproliferativne bolezni. Potrebni so dodatni diagnostični postopki in usmerjeno zdravljenje. Izid bolezni je običajno neugoden za bolnika kljub poskusu zdravljenja s kemoterapevtiki.
Descriptors		MULTIPLE MYELOMA LYMPHOMA, B-CELL ENDOTHELIUM, VASCULAR AGED