Author/Editor		Petrovič, Danijel; Legan, Mateja
Title		Apoptosis, proliferation and pathohistological changes in diffuse and distal coronary artery disease
Type		članek
Source		In: Štiblar-Martinčič D, Petrovič D, editors. Cardiovascular diseases. Proceedings of the 32nd memorial meeting devoted to professor Janez Plečnik, International symposium in memory of professor Rene Favaloro; 2001 Dec 6-8; Ljubljana. Ljubljana: Medical faculty,
Publication year		2001
Volume		str. 207-11
Language		eng
Abstract		The aim of the study was to investigate the pathohistological characteristics of atherosclerotic lesions and to evaluate the role of apoptosis or programmmed cell death in diffuse and distal coronary artery disease. The study included 59 patients who underwent coronary artery bypass grafting coupled with coronary endarterectomy due to diffuse and distal coronary artery disease. Pathohistological analysis of atherosclerotic lesions showed in 13 case (22%) fibromuscular layers - type IV lesion, in 9 case (15.3%) fibromuscular layers -type V lesion, in 13 cases (22%) predominantly calcified fibrous tissue - type VII lesion, and in 24 cases (40.7%) predominantly fibrous tissue - type VIII lesion. TUNEL-positive cells were observed in 4 endarterectomy sequesters (20%) of subjects with diffuse and distal coronary artery disease. TUNEL-positive cells were demonstrated in the area of mononuclear infiltrates as well as in the vessel wall. The percentage of TUNEL-positive cells in mononuclear infiltrates was 0.4 %. Intense mononuclear infiltrates in tunica intima were found in 50 % sequesters, and they consisted of macrophages (40%), lymphocytes T (17%), lymphocytes B (14%). In the area of infiltrates the proportion of MIB-1-positive cells was 2.7%, which was higher than in the intima outside the area of infiltrates (0.5%). In conclusion, apoptosis, which is confined to mononuclear infiltrates, is most likely involved in the development of diffuse and distal coronary artery disease, however the percentage of apoptotic cells is low (0.5%). (Abstract truncated at 2000 characters).
Descriptors		CORONARY DISEASE APOPTOSIS CORONARY ARTERY BYPASS