Author/Editor		Poredoš, Pavel
Title		Endothelial dysfunction in diffuse and distal coronary heart disease
Type		članek
Source		In: Štiblar-Martinčič D, Petrovič D, editors. Cardiovascular diseases. Proceedings of the 32nd memorial meeting devoted to professor Janez Plečnik, International symposium in memory of professor Rene Favaloro; 2001 Dec 6-8; Ljubljana. Ljubljana: Medical faculty,
Publication year		2001
Volume		str. 213-9
Language		eng
Abstract		The vascular endothelium is an important regulatory organ in maintaining cardiovascular bomeostasis. Endothelial dysfunction, which is predominantly caused by decrease of NO bioactivity, occurs early in the course of atherosclerosis in response to cardiovascular risk factors (hypertension, hypercholesterolemia, diabetes). Disturbances of the vasomotor function of the epicardial conductance arteries are fundamental abnormalities of coronary blood flow in atherogenesis, and impaired endothelial vasodilation is the predominant mechanism underlying inappropriate-paradoxical vasoconstriction. However, endothelial dysfunction may also extend to the coronary microcirculation. With respect to the clinical presentation of coronary artery disease, endothelial vasodilator dysfunction appears to play a causative role in triggering of myocardial ischemia in stable angina pectoris, to aggravate sequelae of acute ischaemic syndrome and might be the primary underlying mechanism in some patients with syndrome X. Further, in this article therapeutic interventions for improvement of the endothelial dysfunction are discussed.
Descriptors		CORONARY DISEASE MYOCARDIAL STUNNING ENDOTHELIUM, VASCULAR MYOCARDIAL ISCHEMIA NITROGEN OXIDES SYNDROME X