| Author/Editor | Pastore, G; Magnani, C; Verdecchia, A; Pession, A; Viscomi, S; Coebergh, JW; Oberaigner, W; Storm, H; Aareleid, T; Pompe-Kirn, V | |
| Title | Survival of childhood lymphomas in Europe, 1978-1992: a report from the EUROCARE study | |
| Type | članek | |
| Source | Eur J Cancer | |
| Vol. and No. | Letnik 37, št. 6 | |
| Publication year | 2001 | |
| Volume | str. 703-10 | |
| Abstract | In most developed countries, malignant lymphomas account for 10-15% of all cancers occurring among children aged 0-14 years. The present study estimates survival after a diagnosis of lymphoma in childhood, based on the EUROCARE II database which includes 34 population-based cancer registries from 17 European countries. The survival pattern of children with malignant lymphoma diagnosed in 1985-1989 is reported, as well as the time trends since 1978. The analyses focus on Hodgkin's disease (HD, 1696 cases) and on non-Hodgkin's lymphoma (NHL, 2255 cases including Burkitt's lymphoma and unspecified lymphomas). For HD, the European weighted average 5-year survival rate was 93% (95% confidence interval (CI) 82-98) in 1985-1989. The survival rates were not affected by either age or gender. 5-year survival rates ranged from 68% (95% CI 34-90) in Estonia to 96% (95% CI 92-98) in Germany and 100% (95% CI 57-100) in Slovenia. Multivariate analyses for the time period 1978-1989 gave little suggestion of an improvement in survival over the later time periods of diagnosis. For NHL, the European weighted average 5-year survival rate was 74% (95% CI 67-80) in 1985-1989. Gender did not influence the survival rate. Children in the age group 0-4 years had a poorer prognosis compared with older cases (5-year rate: 66% versus 77% in the pool). 5-year survival rates ranged from 53% (95% CI 30-76) (Estonia) to 83% (95% CI 62-94) in France and 83% (95% CI 66-92) in Scotland. Multivariate analysis show a decreasing HR for the more recent periods of diagnosis from 1 in 1978-1981 to 0.67 (95% CI 0.56-0.79) in 1982-1985 to 0.48 (95% CI 0.40-0.57) in 1986--1989. Exploratory analysis, conducted including the cancer registries which provided cases diagnosed until 1992, show a positive trend over time for both types of lymphoma. | |
| Descriptors | LYMPHOMA CHILD PROGNOSIS EUROPE SURVIVAL RATE MULTIVARIATE ANALYSIS PROPORTIONAL HAZARDS MODELS REGISTRIES RESIDENCE CHARACTERISTICS |