Author/Editor		Domanovič, Dragoslav
Title		Artificial oxygen carriers
Type		članek
Source		In: Intenzivna nega in terapija. 4. podiplomski seminar Zdravljenje s krvjo v kirurgiji; 2001 dec 13-15; Portorož. Ljubljana: Zavod RS za transfuzijo krvi,
Publication year		2001
Volume		str. 52-61
Language		eng
Abstract		The artificial oxygen carrying red cell substitutes are currently under development for use in a variety of surgery and trauma-related clinical conditions. The need for such fluids continues to be driven by the shortage of donor blood, the complex logistics of blood banking, the risk of virally transmitted diseases, current transfusion practices, and the projected increased demand for blood products in the future.The effort to develop a replacement for the red cell component has evolved over the last century and has presented a number of significant challenges including safety and efficacy concerns. Recent progress in understanding the fundamental interactions of hemoglobin (Hb) with the body at the molecular, cellular and tissue levels has led to the production of improved red cell substitutes suitable for clinical testing. Currently, few products are being tested for a variety of applications including trauma, surgery, sepsis, cancer and anemia. Although some of these trials were unsuccessful, the majority of the available products exert no toxicity or only low level side effects. Encouraging results in early clinical trials with oxygen-carrying fluids support further development of these products and have increased the hope that a usable oxygen-carrying fluid will soon be available for clinical use. The purpose of this review is to provide up-to-date information on the status of these products with special emphasis on pre-clinical and clinical experience.
Descriptors		BLOOD SUBSTITUTES FLUOROCARBONS OXYHEMOGLOBINS HEMOGLOBINS LIPOSOMES