Author/Editor     Cimerman, Nina
Title     Importancia de la cistatina c en el asma
Type     članek
Source     SIIC Salud ???
Publication year     2001
Volume     str. 1-8
Language     spa
Abstract     Human cystatin C, a potent inhibitor of cysteine proteinases, has been recently proposed to be a better marker of glomerular filtration rate than creatinine. In order to determine the effect of asthma pathogenesis, therapy, circadian rhythm and renal function on serum cystatin C the 24-hour concentration patterns of cystatin C and creatinine were followed i samples colected every 4h from steroid-independent and steroid-dependent asthmatics before and after one-week treatment with methylprednisolone and cyclosporin A. For the first time the effect of two drugs on cystatin C was demonstrated in a clinical study; methylprednisolone increased and cyclosporin A decreased serum cystatin C concentrations. Little or no significant effects of time on cystatin C and creatinine concentrations were observed in healthy and asthmatic sera indicating that the time of blood sampling does not compromise the results of quantitative measurements over the course of a day. Significantly higher cystatin C concentrations were found in asthmatic patients comapred to controls accompanied by no apparent changes in serum creatinine, which supports the need for further evaluation of cystatin C as a marker of glomerular filtration rate determination in asthma. Additionaly increased serum concentrations of cystatin C in asthmatic patients suggest its role in the pathogenesis of asthma.
Descriptors     ASTHMA
CYSTATINS
METHYLPREDNISOLONE
CYCLOSPORINE
CIRCADIAN RHYTHM
CREATINE
GLOMERULAR FILTRATION RATE