Author/Editor		Buturović-Ponikvar, Jadranka; Rus, Rina R; Kenda, Rajko B; Bren, Andrej F; Ponikvar, Rafael R
Title		Low-flux versus high-flux synthetic dialysis membrane in acute renal failure: prospective randomized study
Type		članek
Source		Artif Organs
Vol. and No.		Letnik 25, št. 12
Publication year		2001
Volume		str. 946-50
Language		eng
Abstract		The influence of dialyzer membrane on the morbidity and mortality of patients with acute renal failure remains a matter of debate. The aim of the prospective randomized clinical study was to assess the influence of the flux of a synthetic dialyzer membrane on patients' survival rate, restitution of renal function, and duration of hemodialysis treatment of patients with acute renal failure as a part of multiorgan failure. Seventy-two patients treated in intensive care units of the University medical center Ljubljana were randomized according to the dialyzer used throughout the duration of hemodialysis treatment. There were 38 patients in the low-flux group (dialyzer F6, low-flox polysuphone, Fresenius, Bad Homburg, Germany) and 34 patients in the high-flux group (dialyzer Filtral 12, sulphonated high-flux polyacrylonitrile, Hospal, Industrie Meyzieu, France). Both groups were balanced in terms of sex, age, APACHE II score, oligouria before dilaysis, cause of acute renal failure, innotropic support, mechanical ventilation, and the number of failing organs. The patients' survival rate was 18.7% in the low-flux group and 20.6% in the high-flux group. Ten patients (26.3%) recovered their renal function in the low-flux group and 8 (23.5%) in the high-flux group. Hemodialysis treatment lasted 11.2 days in the low-flux and 10.7 days in the high-flux group. An analysis of subgroups with a lower mortality rate (subgroup of patients without oliguria and subgroup of patients with less than 4 failed organ systems did not show significant differences between the low-flux and high-flux groups in terms of survival rate, recovery of renal function, and duration of hemodialysis treatment. In conslusion, no significant differences were found in the results of low-flux versus high-flux synthetic membrane dialyzer treatment in patients with acute renal failure as a part multiorgan failure in terms of survival rate... (Abstract truncated at 2000 characters).
Descriptors		KIDNEY FAILURE, ACUTE HEMODIALYSIS MEMBRANES, ARTIFICIAL HEMODIALYSIS SOLUTIONS ACRYLONITRILE SURVIVAL RATE BIOCOMPATIBLE MATERIALS PROSPECTIVE STUDIES TREATMENT OUTCOME OLIGURIA