Author/Editor		Avčin, T; Cimaz, R; Meroni, PL
Title		Recent advances in antiphospholipid antibodies and antiphopsholipid syndromes in pediatric populations
Type		članek
Source		Lupus
Vol. and No.		Letnik 11, št. 1
Publication year		2002
Volume		str. 4-10
Language		eng
Abstract		In recent years, antiphospholipid antibodies (aPL) and their associated clinical features have been recognized increasingly in various pediatric autoimmune and non-autoimmune diseases. Pathogenic mechanisms involved in pediatric antiphospholipid syndrome (APS) appear to be the same as in adults. However, since pediatric patients do not have prothrombotic risk factors present in adults, there clearly are differences in the spectrum of clinical findings. The frequency of aPL-related thrombotic events is generally low in pediatric populations. On the other hand, various commonly acquired infections are likely to be responsible for higher percentage of non-pathogenic and transient aPL in childhood. Such points have to be considered in clinical judgment of elevated aPL in children. In this review we summarize the recent data on the prevalence and clinical significance of aPL in neonates, children and adolescents.
Descriptors		ANTIPHOSPHOLIPID SYNDROME ANTIBODIES, ANTIPHOSPHOLIPID ANTIBODIES, ANTICARDIOLIPIN CHILD LUPUS ERYTHEMATOSUS, SYSTEMIC ARTHRITIS, JUVENILE RHEUMATOID NERVOUS SYSTEM DISEASES HEMATOLOGIC DISEASES INFECTION