Author/Editor		Takač, Iztok
Title		Diagnostični postopki pri raku endometrija
Translated title		Diagnostic procedures in endometrial cancer
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 40, št. 3
Publication year		2001
Volume		str. 325-33
Language		slo
Abstract		The most frequent sign of endometrial cancer is postmenopausal bleeding. In the early cancer stages, some women show no symptoms of the disease. Clinical examination reveals especially advanced forms of cancer while early forms are revealed by hysteroscopy and curettage, which is still the golden standard for diagnosing this disease. Ultrasound allows a fairly reliable evaluation of the affection of the uterine wall and the spread of malignant tissue in the abdominal cavity. The same is true for computer tomography and nuclear magnetic resonance. Tumor markers are not specific of endometrial cancer. Steroid hormone receptors are significant guides in planning of treatment and predicting the course of disease. The latter also depends on the DNA content in cancer cells. The part played by oncogens in endometrial cancer is not yet clarified. Immunohistochemical methods are a mean of defining some rare endometrial malignomas.
Summary		Najpogostejši znak raka endometrija je krvavitev po menopavzi. Nekatere ženske v zgodnjih stadijih raka nimajo simptomov bolezni. S kliničnim pregledom lahko ugotovimo predvsem napredovale oblike raka. Zgodnje oblike raka ugotavljamo s histeroskopijo in abrazijo, ki je še vedno zlati standard diagnoze te bolezni. Ultrazvok omogoča dokaj zanesljivo oceno prizadetosti stene maternice in razširjenosti malignega tkiva v trebušni votlini. Enako velja za računalniško tomografijo in magnetno resonanco. Tumorski označevalci niso specifični za rak endometrija. Receptorji steroidnih hormonov so pomembno vodilo pri načrtovanju zdravljenja in napovedi poteka bolezni. Slednja je odvisna tudi od vsebnosti DNA v rakastih celicah. Vloga onkogenov pri raku endometrija še ni povsem pojasnjena. Z imunohistokemičnimi metodami lahko opredelimo nekatere redke malignome endometrija.
Descriptors		ENDOMETRIAL NEOPLASMS UTERUS HYSTEROSCOPY TOMOGRAPHY, X-RAY COMPUTED MAGNETIC RESONANCE IMAGING FLOW CYTOMETRY