Author/Editor		Bartolić, Andrej
Title		Močnostni spekter nihanja med mirno stojo pri bolnikih s Parkinsonovo boleznijo
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		2001
Volume		str. 61
Language		slo
Abstract		Backgroud Parkinson's disease (PD) is a slowly progressive, degenerative disorder of the substantia nigra of unknown aetiology. The main pathomorphological finding in PD is the loss of dopaminergic neurons in the substantia nigra pars compacta, which results in deficiency of the neurotransmitter dopamine in the striatum. PD is an akinetic-rigid syndrome with the main clinical features of tremor, rigidity, bradikinesia and postural instability. Although postural instability has a big impact on the parkinsonian patients' quality of life, it can be only poorly controlled by antiparkinsonian treatment. Aim. Besides PD, postural instability can also result from diseases of the vestibular system, cerebellum, diabetes mellitus, effects of various drugs or it can be a feature of old ageing. The aim of the first part of our work was to measure the maintenance of equilibrium during free stance in a group of young and a group of senior healthy persons in order to assess the influence of age on postural stability. In the second part of our work we intended to measure the maintenance of equilibrium during free stance in a group of patients with PD before and after the administration of the dopaminergic agonist apomorfin. We wanted to establish the influence of apomorphine on postural instability. Hypoteses. In our work we measured the maintenance of equilibrium during free stance and performed a clinical motor examination in healthy subjects and in patients with PD before and after the administration of apomorphine in order to test the next two hipotheses. 1. The maintenance of equilibrium during free stance in healthy subjects (aged 23-01) is not affected by age. 2. The dopaminergic agonist apomorphine can significantly change the power spectrum of body oscillations during free stance in patients with PD. (Abstract truncated at 2000 characters)
Descriptors		PARKINSON DISEASE EQUILIBRIUM SENSATION DISORDERS POSTURE NEUROLOGIC EXAMINATION SEVERITY OF ILLNESS INDEX STATISTICS, NONPARAMETRIC