Author/Editor		Golob, Mirjam; Jensterle, Mojca
Title		Zgodnje morfološke in funkcijske spremembe perifernih arterij pri bolnikih z aterosklerotično boleznijo arterij spodnjih udov
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		2001
Volume		str. 46
Language		slo
Abstract		Background. Atherosclerosis is a chronic, degenerative disease of arterial wall that is caused and aggravated by numerous risk factors. Coronary artery disease, central nervous system (CNS) arteries atherosclerosis and peripheral arteries occlusive disease (PAOD) of the lower limbs are the most common clinical manifestations of atheroslerosis. Early progression of atherosclerosis is characterised by dysfunction of endothelial cells (impaired vasodilatation of peripheral arteries) and by structural changes of arterial wall (thickening of the intima-media (IM)). There is a large amount of scientific data proving that nature of the disease is systemic. Therefore, in a patient diagnosed with one of the mentioned manifestations we can also expect other sections of arterial system to be impaired. These changes are presumably spread across majority of sections of the arterial system. We can study and follow them noninvasively by using new high-resolution ultrasound methods. Aim and hypotesis. The aim of our research was to determine whether patients with diagnosed PAOD of lower limbs have any early subclinical functional or structural arterial wall disturbances in other sections of the arterial system. We tested the following hypothesis: PAOD uatients without clinical signs of CNS arteries atherosclerosis have asymptomatic morphological changes in carotid arteries (CA) and endothelial dysfunction of pgripheral (brachial) arteries. (Abstract truncated at 2000 characters)
Descriptors		ATHEROSCLEROSIS ARTERIAL OCCLUSIVE DISEASES PERIPHERAL VASCULAR DISEASES CAROTID ARTERIES BRACHIAL ARTERY AGED INTERMITTENT CLAUDICATION ENDOTHELIUM, VASCULAR BODY MASS INDEX PROSPECTIVE STUDIES