Author/Editor		Tomažič, Janez
Title		Motnje imunskega odziva pri bolnikih z aidsom
Translated title		Immune response disturbances in aids patients
Type		članek
Source		In: Paver-Eržen V, Manohin A, Hribar-Habinc M, editors. Kontinuirano podiplomsko izobraževanje iz anesteziologije (CME). 10. tečaj FEEA; 2002 mar 22-24; Portorož. Ljubljana: Slovensko združenje za anesteziologijo in intenzivno medicino,
Publication year		2002
Volume		str. 201-12
Language		slo
Abstract		Aids is a condition resulting from chronic infection by the human immunodeficiency virus (HIV), in which the damage to the immune system leaves the host increasingly vulnerable to opportunistic infections and malignancies. The characteristic deficit in HIV infection and aids is a progressive decline in the number and activity of CD4+ cells (T helper cells), which are required to generate and sustain an immune response to HIV and other pathogens. Immune response to HIV appears shortly after primary infection. The production of HIV specific antibodies is one of the first signs of infection (seroconversion). Cell-mediated response (an immune response based on the activation of antigen-specific T cells) is a critical component of the body's defense aginst HIV. Components of cell-mediated immunity include activation of HIVspecific CDB+ cells (cytotoxic T cells), lymphocyte proliferation and secretion of cytokines and chemokines. The decline in cellmediated immunity during HIV infection is associated with progression of aids.
Descriptors		ACQUIRED IMMUNODEFICIENCY SYNDROME IMMUNITY, CELLULAR CD8-POSITIVE T-LYMPHOCYTES CD4-POSITIVE T-LYMPHOCYTES MONOCYTES MACROPHAGES CYTOKINES