Author/Editor		Bilban, M; Bilban-Jakopin, C; Vrhovec, S
Title		Incidence of chromosomal aberrations and micronuclei in cave tour guides
Type		članek
Source		Neoplasma
Vol. and No.		Letnik 48, št. 4
Publication year		2001
Volume		str. 278-84
Language		eng
Abstract		An analysis of structural chromosomal aberrations (SCA) and micronucleus tests (MN) were performed in 38 subjects, cave tour guides and in appropriate control group. The dominant type of chromosomal aberrations in tourist guides were chromosomal breaks (0.013 per cell) and acentric fragments (0.011 per cell). In the control group, these aberrations were present up to 0.008 on cells. Considering the analysed cells of the guides in total (33,556), the incidence of dicentric and rings range is below 0.0008 on cells, even though three dicentric and ring chromosome were found already in the first 1000 in vitro metaphases of some guides. Only 0.0003 dicentrics and neither other translocations were found in control group (ambiental exposure). The incidence of micronuclei in cytokinesis blocked lymphocytes ranged from 12-32 per 500 CB cells in the cave tour guides and from 4-11 per 500 CB cells in control group. Measurements of radon and its daughters were performed at different locations in the cave. Annual doses from 40-60 mSv were estimated per 2000 work hours for cave guides. The changes found in the genome of somatic cells may be related to the exposure doses of radon and its daughters, although smoking should not be ignored.
Descriptors		OCCUPATIONAL EXPOSURE RADON RADON DAUGHTERS CHROMOSOME ABERRATIONS MICRONUCLEUS TESTS CHROMOSOME BREAKAGE SMOKING