Author/Editor		Coebergh, J-W; Pastore, G; Gatta, G; Corazziari, I; Kamps, W; Pompe-Kirn, V
Title		Variation in survival of European children with acute lymphoblastic leukaemia, diagnosed in 1978-1992: the EUROCARE study
Type		članek
Source		Eur J Cancer
Vol. and No.		Letnik 37, št. 6
Publication year		2001
Volume		str. 687-94
Language		eng
Abstract		The aim of this study was to provide a comparative description of geographical variations and time trends in the populationbased survival of European children with acute lymphoblastic leukaemia (ALL). Data on 13 344 newly diagnosed children (0-14 years) with ALL were included in the EUROCARE study and were collectedwere collected by 34 population-based cancer registries (four comprising only childhood malignancies), operating in 17 countries (four in Scandinavia, two in Southern Europe, three in Eastern Europe, six in Continental Europe and two in the UK). Age-specific crude survival rates were estimated for boys and girls according to country for the period 1985-1989 and in adjusted form to attain comparability. Overall pooled and weighted rates were estimated as European standards. Children dead at diagnosis or diagnosed only through a death certificate were excluded. Geographical variation was also estimated by calculating the relative death rate with respect to the pooled overall European rate. After adjustment for age, gender and country, a Cox regression analysis was used to estimate time trends in survival. Survival was compared with that in the USA, Japan, Canada and Australia. During 1985-1989, the 1-year survival rate varied from 99 to 79%, the 5-year survival rate from over 80 to 56% (with the exception of Estonia; 34%; 95% confidence interval (CI) 20-52) among the various countries; the European weighted means were 90 (95% CI 87-93) and 72% (95% CI 69-75), respectively. Survival was particularly favourable in (south) Sweden, Finland, Germany and The Netherlands and rather unfavourable in Estonia and (surprisingly) France, where only 4% of its population was covered by the participating registries. (Abstract truncated at 2000 characters).
Descriptors		LEUKEMIA, LYMPHOCYTIC, ACUTE CHILD AGE FACTORS SEX FACTORS SURVIVAL RATE RESIDENCE CHARACTERISTICS REGISTRIES EUROPE