Author/Editor		Medved, Robert; Korošec, Sara; Virant, Irena; Meden-Vrtovec, Helena
Title		Spodbujanje ovulacije v postopku IVF-ET
Translated title		Ovarian stimulation for IVF-ET procedure
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 71, št. 3
Publication year		2002
Volume		str. 177-80
Language		slo
Abstract		Background. It is well known that the efficiency of fertilization in vitro depends on the number of transferred embryos. To provide the conditions for the development of a higher number of ovarian follicles, from which a higher number of oocytes can be obtained, various regimens of ovarian stimulation have been used. Ovulation stimulation in in vitro fertilization-embryo transfer (IVF-ET) is performed by gonadotropins alone, by a combination of gonadotropins plus gonadotropin-releasing hormone (GnRH) agonists or by a combination of gonadotropins plus GnRH antagonists. The use of gonadotropins alone is being abandoned. In most centres involved in the treatment of infertility and IVF procedures, the combination of gonadotropins and GnRH agonists is the most frequent regimen used for ovarian stimulation, whereas GnRH antagonists are in the phase of being introduced in the routine clinical work. Conclusions. At the Department of Obstetrics and Gynecology in Ljubljana, ovarian stimulation with gonadotropins alone was abandoned at the end of 2000. In all the patients treated at our centre ovarian stimulation is currently done using the combination of gonadotropins and GnRH agonists, since the results are much better. Further clinical research will elucidate the possibilitiers offered by GnRH antagonists introduced in routine clinical work.
Summary		Izhodišča. Iz spoznanja, da je uspešnost postopka IVF-ET odvisna od števila prenesenih zarodkov, so se uveljavile različne metode spodbujanja ovulacije, ki omogočajo razvoj večjega števila ovarijskih folikov, iz katerih pridobivamo večje število jajčnih celic. V postopku IVF-ET uporabljamo več različnih načinov spodbujanja ovulacije: z gonadotropini, s kombinacijo gondotropinov in agonistov GnRH ter s kombinacijo gonadotropinov in antagonistov GnRH. Uporaba samih gonadotropinskih preparatov za spodbujanje ovulacije v postopku zunajtelesne oploditve se vse bolj opušča. V večini ustanov, ki se ukvarjajo z zdravljenjem neplodnosti in postopkom zunajtelesne oploditve, sedaj uporabljamo predvsem kombinacijo agonistov GnRH z gondotropini. Uporaba antagonistov GnRH je zaenkrat še v fazi uvajanja v redno klinično prakso. Zaključki. Na Ginekološki kliniki v Ljubljani smo ob koncu leta 2000 prenehali s spodbujanjem ovulacije samo z gonadotropini in pri vseh bolnicah, ki se zdravijo pri nas s postopkom IVF-ET, spodbujamo ovulacijo s kombinacijo gonadotropinov in agonistov GnRH zaradi boljših rezultatov IVF-ET postopkov pri bolnicah, zdravljenih na ta način. Klinično raziskovalno delo na področju uporabe antagonistov GnRH pa bo pokazalo na možnosti uvedbe antagonistov GnRH v klinično prakso.
Descriptors		FERTILIZATION IN VITRO EMBRYO TRANSFER OVULATION INDUCTION GONADOTROPINS, CHORIONIC