Author/Editor		Popović, Petra; Jarc-Vidmar, Martina; Brecelj, Jelka; Hawlina, Marko
Title		Slikovna elektroretinografija v primerjavi s kinetično in statično perimetrijo in vidno ostrino pri pigmentni retinopatiji
Translated title		Pattern electroretinography in relation to kinetic and static perimetry and visual acuity in retinitis pigmentosa
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 71, št. Suppl 2
Publication year		2002
Volume		str. II-119-24
Language		slo
Abstract		Background. This study was conducted to assess whether pattern ERG is a sensitive test in evaluating the retinal function in patients with retinitis pigmentosa. We wanted to determine how pattern ERG, reflecting the activity of inner retinal layers, is related to other psychophysical tests such as perimetry and visual acuity. Methods. An analysis was performed on 50 eyes of 25 patients with typical rod: one retinitis pigmentosa. The standard Snellen visual acuity was tested. Visual field sensitivity was measured with automated static perimetry (Octopus G2 program) where mean defect was taken as an index of visual field loss. In kinetic perimetry (Goldmann).the average radius of the visual field measured with target 11/4 and V/4 was calculated. Transient pattern ERG and all five flash ERG responses were also measured according to ISCEV standards. Amplitudes of pattern ERG P50 and N95 waves were compared to results of visual acuity and visual field testing. Results. In our group of 25 RP patients with visual acuity ranging from 0.16 to 1.0, PERG responses were preserved much better than full field ERGs. 72% of them had still recordable PERG responses, while 48% had cone and only 32% maximal responses. Scotopic rod responses were extinguished in all eyes. The normalized amplitudes of the PERG responses were also much higher (43.5%) than cone (22.5%) or maximal responses (4.5%). A strong correlation of both P50 and N95 amplitudes with Octopus mean defect index was found. In kinetic perimetry the correlation with PERG amplitudes was also high, but it was better with II/4 than with V/4 target. Patients with high preserved ERG responses had good visual acuity. In all patients with visual acuity less than 0.4 both flash and pattern ERG responses were already absent. (Abstract truncated at 2000 characters).
Summary		Izhodišča. Želeli smo oceniti vlogo slikovne elektroretinografije kot nove diagnostične metode pri bolnikih s pigmentno retinopatijo. Zanimalo nas je, kako je izvid slikovne elektroretinografije povezan z izvidi drugih funkcionalnih preiskav (vidnim poljem in vidno ostrino), ki jih pri vsakem bolnikovem obisku izvajamo rutinsko. Metode. V raziskavo smo vključili 25 bolnikov obeh spolov s tipično obliko pigmentne retinopatije. Določili smo jim vidno ostrino. Občutljivost vidnega polja smo merili z računalniško podprtim perimetrom Octopus (program G2), kjer smo pri analizi rezultatov upoštevali kazalec povprečni odklon, in z Goldmannovim perimetrom (znački II/4 in V/4), s katerim smo izračunali povprečno širino še ohranjenega vidnega polja. Vsem preiskovancem smo opravili tudi bliskovno in slikovno elektroretinografijo v skladu z mednarodnimi standardi. Pri analizi rezultatov smo primerjali amplitude valov P50 in N95 slikovne elektroretinografije z izvidi vidnih polj, dobljenih s kinetično in statično perimetrijo. Ugotavljali smo tudi, v kolikšni meri vidna ostrina vpliva na amplitudo slikovnega elektroretinograma. Rezultati. V skupini 25 bolnikov z RPz vidno ostrino med 0,16 in 1,0 so bili odzivi slikovne ERG ohranjeni dlje kot bliskovni ERG. 72% bolnikov je imelo ohranjene odzive slikovne ERG, pri bliskovni ERG pa je imelo 48% bolnikov ohranjene odgovore čepnic in le 32% maksimalne odgovore. Odgovori paličnic so bili ugasli pri vseh bolnikih. Tudi povprečne amplitude so bile mnogo višje pri slikovnih ERG (43,5%) kot pri odgovorlh čepnic (22,5%) ali maksimalnih odgovorih (4,5%). Amplitude valov P50 in N95 slikovne ERG so bile močno povezane s povprečnim odklonom. Visoka je bila tudi povezava slikovnega ERGs povprečno širino vidnega polja, merjeno s kinetično perimetrijo, boljša za značko II/4 kot za V/4. (Izvleček skrajšan pri 2000 znakih).
Descriptors		RETINITIS PIGMENTOSA ELECTRORETINOGRAPHY PERIMETRY VISUAL ACUITY