Author/Editor | Sherer, Yaniv; Tenenbaum, Alexander; Praprotnik, Sonja; Shemesh, Joseph; Blank, Miri; Fisman, Enrique Z; Harats, Dror; George, Jacob; Levy, Yair; Peter, James B | |
Title | Coronary artery disease but not coronary calcification is associated with elevated levels of cardiolipin, beta-2-glycoprotein-I, and oxidized LDL antibodies | |
Type | članek | |
Source | Cardiology | |
Vol. and No. | Letnik 95 | |
Publication year | 2001 | |
Volume | str. 20-4 | |
Language | eng | |
Abstract | Background: Autoimmune factors have been shown to play a role in atherosclerosis. The aim of this study is to correlate 5 autoantibodies (anticardiolipin, anti-CL, beta2-glycoprotein-I, beta2GPI, phosphatidylcholine, oxidized lowdensity lipoprotein, oxLDL, endothelial cell) with the presence of coronary heart disease, angiographic findings, and with coronary artery calcification. Methods: The levels of the 5 autoantibodies and a control antifibro blast line of 126 coronary heart disease patients and 20 healthy controls were measured. Fifty-one patients underwent coronary angiography, and 98 patients had coronary artery calcium determination using spiral computerized tomography (dual mode). Results: Levels of 3 autoantibodies (anti-CL, (32GPI, oxLDL) were significantly elevated in coronary heart disease patients compared with controls (p < 0.001,p = 0.001, p < 0.001, respectively). Within the subgroup of patients with significant coronary artery stenosis, anti-CL antibodies were also elevated (p =0.0081. No correlation was found between antiCL, and anti-beta2GPI autoantibody levels and coronary calcium scores as measured by spiral computerized tomography. However, anti-oxLDL antibodies were raised in patients with no calcification detected by spiral computerized tomography, compared with the patients with any coronary calcification (p = 0.046). Conclusion: Anti-CL, beta2GPl and oxLDL antibodies are elevated in coronary heart disease patients regardless of coronary calcification. | |
Descriptors | CORONARY DISEASE AUTOANTIBODIES CARDIOLIPINS GLYCOPROTEINS LIPOPROTEINS, LDL CHOLESTEROL AGED TOMOGRAPHY, X-RAY COMPUTED CASE-CONTROL STUDIES CALCINOSIS BIOLOGICAL MARKERS |