Author/Editor     Sherer, Yaniv; Tenenbaum, Alexander; Praprotnik, Sonja; Shemesh, Joseph; Blank, Miri; Fisman, Enrique Z; Harats, Dror; George, Jacob; Levy, Yair; Peter, James B
Title     Coronary artery disease but not coronary calcification is associated with elevated levels of cardiolipin, beta-2-glycoprotein-I, and oxidized LDL antibodies
Type     članek
Source     Cardiology
Vol. and No.     Letnik 95
Publication year     2001
Volume     str. 20-4
Language     eng
Abstract     Background: Autoimmune factors have been shown to play a role in atherosclerosis. The aim of this study is to correlate 5 autoantibodies (anticardiolipin, anti-CL, beta2-glycoprotein-I, beta2GPI, phosphatidylcholine, oxidized lowdensity lipoprotein, oxLDL, endothelial cell) with the presence of coronary heart disease, angiographic findings, and with coronary artery calcification. Methods: The levels of the 5 autoantibodies and a control antifibro blast line of 126 coronary heart disease patients and 20 healthy controls were measured. Fifty-one patients underwent coronary angiography, and 98 patients had coronary artery calcium determination using spiral computerized tomography (dual mode). Results: Levels of 3 autoantibodies (anti-CL, (32GPI, oxLDL) were significantly elevated in coronary heart disease patients compared with controls (p < 0.001,p = 0.001, p < 0.001, respectively). Within the subgroup of patients with significant coronary artery stenosis, anti-CL antibodies were also elevated (p =0.0081. No correlation was found between antiCL, and anti-beta2GPI autoantibody levels and coronary calcium scores as measured by spiral computerized tomography. However, anti-oxLDL antibodies were raised in patients with no calcification detected by spiral computerized tomography, compared with the patients with any coronary calcification (p = 0.046). Conclusion: Anti-CL, beta2GPl and oxLDL antibodies are elevated in coronary heart disease patients regardless of coronary calcification.
Descriptors     CORONARY DISEASE
AUTOANTIBODIES
CARDIOLIPINS
GLYCOPROTEINS
LIPOPROTEINS, LDL CHOLESTEROL
AGED
TOMOGRAPHY, X-RAY COMPUTED
CASE-CONTROL STUDIES
CALCINOSIS
BIOLOGICAL MARKERS