Author/Editor		Novaković, Srdjan; Jezeršek-Novaković, Barbara
Title		A brief overview of the tumor vaccines through the last decade
Translated title		Kratek pregled priprave tumorskih vakcin v zadnjem desetletju
Type		članek
Source		Radiol Oncol
Vol. and No.		Letnik 36, št. 1
Publication year		2002
Volume		str. 53-62
Language		eng
Abstract		How to destroy cancer cells without damaging the normal cells? How to make conventional methods of systemic cancer treatment that predominantly comprise cytotoxic drugs more selective and prevent the development of drug resistance? There is an abundance of such guestions that do not have simple answers. If, a few years ago, unselective cytotoxic drugs were the method of choice for the treatment of cancer, in the last 25 years we are witnessing the rapid transition of immunotherapy from the laboratories to the clinics. Among the most attractive and promising immunotherapies for cancer, a special place is reserved for tumor vaccines. Exploiting the latest knowledge in immunology, tumor physiology, as well as in molecular biology, many outstanding approaches for the creation of tumor vaccines have been developed. With no intention to be comprehensive, in the present article some of those approaches are reviewed.
Summary		Kako bi lahko uničili tumorske celice, ne da bi ob tem prizadeli tudi normalne celice v organizmu? Kako bi lahko spremenili sedanje pristope sistemskega zdravljenja, ki temelji predvsem na uporabi citostatikov, da bi le-to delovalo samo na tumorske celice in ne bi prišlo do pojava neobčutljivih celičnih klonov? Takšnih in podobnih vprašanj je pri zdravljenju raka veliko in predstavljajo osnovo za nove predklinične in klinične raziskave s skupnim ciljem odkriti učinkovito zdravilo ali način zdravljenja rakastih bolezni. Čeprav so še pred nekaj leti nesporno prevladovali citostatiki kot najučinkovitejše orožje v boju proti raku, se v zadnjih 25 letih na tem področju vse bolj uveljavlja biološka terapija. Posebej obetavna med biološkimi terapijami je priprava in uporaba tumorskih vakcin. Na osnovi novejših spoznanj s področij imunologije, tumorske fiziologije in molekularne biologije so raziskovalci oblikovali različne nadvse zanimive pristope k oblikovanju tumorskih vakcin. Pričujoči članek predstavlja kratek pregled nekaterih od navedenih pristopov.
Descriptors		NEOPLASMS CANCER VACCINES GENE THERAPY