| Author/Editor | Eržen, M; Možina, A; Bertole, J; Syrjaenen, K | |
| Title | Factors predicting disease outcome in early stage adenocarcinoma of the uterine cervix | |
| Type | članek | |
| Source | Eur J Obstet, Gynecol, Reprod Biol | |
| Vol. and No. | Letnik 101 | |
| Publication year | 2002 | |
| Volume | str. 185-91 | |
| Language | eng | |
| Abstract | Context: Adenocarcinoma (AC) and adenosquamous carcinoma (ASC) comprise the second principal histological types of cervical carcinoma. As compared with the squamous cell cancer (SCC), these lesions are far less frequent, and their epidemiology, natural history and prognostic determinants are less well understood. Objective: Patients with an early stage AC of the uterine cervix diagnosed in our clinic were subjected to detailed analysis for the prognostic determinants. Study subjects:A series of 49 women with early stage (adrenocarcinoma in situ (AIS) to IIB) cervical ACs or ASCs diagnosed and treated in our department during 1995-1999 and subsequently followed-up for a mean of 43.1 +-16.2 (S.D.) months. Main outcome measures: Patients were examined by colposcopy, Papanicolaou (PAP) smear and biopsy. The stage of the disease (FIGO) and tumour histology in operative specimens were recorded, and univariate (Kaplan-Meier) and multivariate survival analysis (Cox) were run to explore the factors predicting disease outcome. Results: Mean age of the women was 44.2+-2.5 (S.D.) years (range 24-81 years), which is significantly (P=0.000) lower than that (49.9+-14.2) of 464 SCC patients in our material. Minority of the women (38.2%) reported any clinical symptoms, but these correlated with the stage (P=0.041). Screening history was acceptable (i.e. screening interval 3 to 4 years) in 56 women, whereas 28 (29.8%) had no previous PAP smear taken. Interpretation errors were established in 17 (23.6%) and sampling errors in 6 (8.3%) of the 72 smears available for re-screening. No colposcopic lesions were found in 29 (30.9%) women. (Abstract truncated at 2000 characters). | |
| Descriptors | CERVIX NEOPLASMS ADENOCARCINOMA PROGNOSIS SURVIVAL ANALYSIS NEOPLASM STAGING VAGINAL SMEARS COLPOSCOPY AGE FACTORS |