Author/Editor		Hojs, Radovan; Gorenjak, Maksimiljan; Ekart, Robert; Dvoršak, Benjamin; Pečovnik-Balon, Breda
Title		Homocysteine and vascular access thrombosis in hemodialysis patients
Type		članek
Source		Ren Fail
Vol. and No.		Letnik 24, št. 2
Publication year		2002
Volume		str. 215-222
Language		eng
Abstract		Background: Vascular access remains the Achilles? heel of successful hemodialysis, and thrombosis is the leading cause of vascular access failure. Hyperhomocystinemia is common in hemodialysis patients and is associated with venous and arterial thrombosis in patients without end-stage renal disease. Subjects and methods: In the study, 65 hemodialysis patients with native arteriovenous fistula were included. Two groups of patients were defined: group A including 45 patients with their vascular access either never or only once thrombosed, and group B including 20 patients with two or more thromboses of their vascular access. We determined serum concentrations of total homocysteine (immunoassay, Abbott) in our patients. Results: In 63 (96.9%) patients, hyperhomocystinemia was presented. There was no statistically significant difference between group A and B regarding age, gender and duration of hemodialysis treatment. Total homocysteine concentrations were higher in group A (42.1 ? 18.6 ?mol/l) than in group B (36.1 ? 18.1 ?mol/l) patients but the difference was small and not statistically significant. Conclusion: We found no significant differences in total homocysteine concentrations between group A (thrombosis non-prone) and group B (thrombosis prone) patients. Our results suggest that thrombosis of native arteriovenous fistulas may not be caused by hyperhomocystinemia in these patients.
Descriptors		HEMODIALYSIS HOMOCYSTEINE CATHETERS, INDWELLING THROMBOSIS