Author/Editor     Hlebič, Gregor
Title     Pomen prokalcitonina kot označevalca okužbe pri akutnem nekrozantnem pankreatitisu
Type     monografija
Place     Ljubljana
Publisher     Medicinska fakulteta
Publication year     2001
Volume     str. 51
Language     slo
Abstract     BACKGROUND: Acute pancreatitis (AP) is an acute inflammatory process of the pancreas, with variable involvement of other regional tissues or remote organ systems. About 25% of patients have a severe AP associated with organ failure and/or local complications. The mortality rate of patients with severe AP with complications remains between 30-50 %. AIM: In the management of patients with severe AP, the most important diagnostic goal is identification of local and systemic complications. In last few years scientists try to find a marker, that could distinguish between mild and severe form of AP and predict complications in the early beginning of the disease. The aim of our study was to establish the place of serum concentration of procalcitonin (PCT), marker of infection, in clinical course of AP. HYPOTHESIS: Our hypotheses were: 1.PCT is an early predictor of the severity of AP. 2.There is a correlation between PCT and other prognostic factors for the assessment of severity in AP. 3.PCT can differentiate between infected and sterile necrosis of pancreas. 4.PCTis an early predictor of development of organ failure. METHODS: As routinely, in all patients we measured blood levels of inflammatory markers and PCT daily up to fourth day of admission and later on, if clinical picture deteriorated and/or infection appeared. We compared PCT with other indicators of severity of acute pancreatitis such as Ranson, APACHE II criteria and C-reactive protein. For statistical processing of data we use one way analysis of variance and Pearson's correlation coefficient. RESULTS: In our prospective study 27 patients with AP were included. According to our criteria 8 patients had mild AP (group 1), 13 patients (group 2) severe AP without organ failure and 6 patients (group 3) severe AP with organ failure. 24 patients survived, 3 died. (Abstract truncated at 2000 characters).
Descriptors     PANCREATITIS, ACUTE NECROTIZING
CALCITONIN
PROGNOSIS
PREDICTIVE VALUE OF TESTS
APACHE
SENSITIVITY AND SPECIFICITY
PROSPECTIVE STUDIES