Author/Editor		Skok, Pavel; Križman, Igor; Skok, Marija
Title		Krvaveča peptična razjeda, nesteroidna protivnetna zdravila in okužba s Helicobacter pylori - prospektivna, kontrolirana, randomizirana raziskava
Translated title		Bleeding peptic ulcer, nonsteroidal anatiinflammatory drugs and Helicobacter pylori infection - a prospective, controlled, randomized study
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 71, št. 6
Publication year		2002
Volume		str. 357-62
Language		slo
Abstract		Background. The explanation of peptic ulcer etiology has changed significantly in the past decade after the clarification of the significance of Helicobacter pylori infection. Aim. To evaluate the effectiveness of Helicobacter pylori eradication in patients with hemorrhaging peptic ulcer and patients with peptic ulcer without complications. Study ethics. The study was approved in 1998 by the Medical Ethics Committee of the Republic of Slovenia (No. 90/09/98). Type of study. Prospective, controlled and randomized study, carried out between 1998-2000. Patients and methods. The study included 80 patients (50 male and 30 female, av.age 57.5 years, SD +- 171, range 2280) in which endoscopy confirmed hemorrhage from peptic ulcer of stomach or duodenum and Helicobacterpylori infection. In all cases endoscopic hemostasis was performed: injection sclerotherapy with diluted adrenalin 1:10,000 and 1 % polidocanol or argon plasma coagulation. The control group was made up of 80 patients (50 male and 30 female, av.age 56.8 years, SD +- 16.8, range 19-80) with peptic ulcer of stomach or duodenum and Helicobacter pylori infection. Infection was confirmed by a rapid urease test and histologic investigation of the gastric mucosa. In all cases the recommended drug combinations were used in the treatment of the infection: a proton pump inhibitor, omeprazol (4 weeks), and combination of antibiotics, claritromycin and metronidazole or with regard to the antibiogram (1 week). The therapeutic success was ascertained endoscopically four weeks after inclusion in the study. Infection eradication was confirmed by the rapid urease test and histologic investigation of the gastric mucosa. (Abstract truncated at 2000 characters).
Summary		Izhodišča. Razlaga etiologije peptične razjede se je v zadnjem desetletju po pojasnitvi pomena okužbe s Helicobacter pylori pomembno spremenila. Namen raziskave. Ugotoviti uspešnost izkoreninjenja okužbe s Helicobacter pylori pri bolnikih s krvavečo peptično razjedo in bolnikih s peptično razjedo brez zapletov. Etičnost raziskave. Raziskavo je odobrila Republiška strokovna komisija za medicinskoetična vprašanja leta 1998 (številka sklepa 90/09/98). Vrsta raziskave. Prospektivna, kontrolirana in randomizirana, potekala je v obdobju 1998-2000. Bolniki in metode. V študijsko skupino smo vključili 80 bolnikov (50 moških in 30 žensk, povp. starosti 57,5 leta, SD +- 17,1 leta, v razponu od 22-80), pri katerih smo endoskopsko potrdili krvavečo peptično razjedo želodca ali dvanajstnika in okužbo s Helicobacter pylori. Pri vseh smo izvršili endoskopsko hemostazo: injekcijsko sklerozacijsko zdravljenje z razredčenim adrenalinom 1:10.000 in 1 % polidokanolom ali argonsko plazemsko koagulacijo. V kontrolno skupino smo vključili 80 bolnikov (50 moških in 30 žensk, povprečne starosti 56,8 leta, SD +- 16,8, v razponu od 19-80) s peptično razjedo želodca ali dvanajstnika, okuženih z bakterijo. Okužbo smo potrdili s hitrim ureaznim testom in histološkim pregledom sluznice želodca. Pri vseh smo okužbo zdravili s priporočenimi kombinacijami zdravil: zaviralcem protonske črpalke, omeprazolom (4 tedne) in antibiotikoma klaritromicinom in metronidazolom ali glede na antibiogram (1 teden). Uspešnost zdravljenja smo ugotavljali endoskopsko štiri tedne po vključitvi v raziskavo. Izkoreninjenje okužbe smo potrdili s hitrim ureaznim testom in histološkim pregledom sluznice želodca. (Izvleček prekinjen pri 2000 znakih).
Descriptors		PEPTIC ULCER HEMORRHAGE HELICOBACTER PYLORI SCLEROTHERAPY ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL SCLEROSING SOLUTIONS PROSPECTIVE STUDIES RANDOMIZED CONTROLLED TRIALS TREATMENT OUTCOME