Author/Editor		Novaković, Srdjan; Fras, Peter A; Jezeršek-Novaković, Barbara
Title		Telomerase activity as a biological marker in some gynecological tumors: comparison with tissue and serum CA 125
Type		članek
Source		In Vivo
Vol. and No.		Letnik 15, št. 4
Publication year		2001
Volume		str. 327-32
Language		eng
Abstract		Background: Since telomerase activity is detectable in cancer cells but not in some normal somatic cells, it has been considered as a potential diagnostic marker as well as a target for possible anticancer strategies. The purpose of this study was to assess the value of telomerase activity determination in some gynecological tumors and to compare it with the CA 125 tissue and serum proftle. Patients and Methods: The telomerase activity was determined in 11 gynecological tumors: 7 ovarian carcinomas, 2 carcinomas of the fallopian tube and 2 cervical carcinomas, and compared to the activity in the normal peritoneal tissue of the same patients. Additionally, the levels of CA 125 were measured in the tumor and normal peritoneum tissue samples as well as in the patients'sera. Results: In ovarian turs, the telomerase activity was detected in 71.4% (5 out of 7), while in the carcinomas of the fallopian tube and cervical carcinomas such activity was not observed. IVegative for telomerase activity were also all samples of peritoneum. The range of CA 125 in the tumor tissue was 99 Ulg - 803667 Ulg of tissue and in the normal peritoneum 71 U/g - 4925 U/g of tissue. Conclusion: In conclusion, telomerase activity could be detected in some of the gynecological tumors, but for clinical use as a diagnostic marker it is inferior to CA 125.
Descriptors		CA-125 ANTIGEN CERVIX NEOPLASMS FALLOPIAN TUBE NEOPLASMS OVARIAN NEOPLASMS TELOMERASE AGE FACTORS ADENOCARCINOMA ADENOCARCINOMA, MUCINOUS CARCINOMA, SQUAMOUS CELL CYSTADENOCARCINOMA, SEROUS ENDODERMAL SINUS TUMOR PERITONEUM SENSITIVITY AND SPECIFICITY TUMOR MARKERS, BIOLOGICAL