Author/Editor		Rener-Primec, Zvonka
Title		Vpliv možganske okvare na različnih mestih na potek infantilnih spazmov
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		2002
Volume		str. 107
Language		slo
Abstract		Background. Infantile spasms (IS) as an epileptic syndrome generally associated with the first year of life and a specific EEG pattern - hypsarrhythmia still represent one of the most serious forms of epilepsy in early childhood. The prognosis is mostly unfavourable and the, final outcome of the disease is often mental retardation and the development of resistant epilepsy. The etiology is heterogeneous and significantly influences the future course of the disease, which is most unfavourable in cases of symptomatic etiology associated with prior encephalopathy. Symptomatic causes include various types of brain damage which may lead to the development of IS and, due to their epileptic nature, unsuccessful treatment and the later development of resistant epilepsy. The objectives of the study were to identify the types and localization of cortical brain lesions in children with IS, compare the focal signs in the clinical picture and EEG, and evaluate their coincidence with the location of brain damage in the CT/MR images. Another objective of the study was to determine the correlation between the location of the cortical lesion and age at the onset of IS, the impact of long-lasting hypsarrhythmia on the cognitive outcome, and to assess the effectiveness of treatment with steroids compared to other antiepileptic drugs. Patients and Methods. The study included 48 patients who, due to first diagnosed IS, were admitted to the University Paediatric Hospital in the period from lst January 1985 to 31st December 1995. Data on risk factors, age at the onset of IS, neurological and development status at the onset of the disease, the form of IS, and the presence of focal signs or partial seizures were retrospectively collected from the medical records. The type of hypsarrhythmia and the presence of focal or regional epileptifom activity and/or slow activity were determined on the basis of EEG reports. (Abstract truncated at 2000 characters).
Descriptors		SPASMS, INFANTILE EPILEPSY, PARTIAL ANTICONVULSANTS ELECTROENCEPHALOGRAPHY CEREBRAL CORTEX INFANT RISK FACTORS RETROSPECTIVE STUDIES TOMOGRAPHY, X-RAY COMPUTED MAGNETIC RESONANCE IMAGING TREATMENT OUTCOME NEUROLOGIC EXAMINATION INTELLIGENCE TESTS CORTICOTROPIN QUADRIPLEGIA PARESIS