Author/Editor		Jenko, Saša
Title		Strukturne študije kompleksov katepsinov s proteinskimi inhibitorji
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		2002
Volume		str. 44
Language		slo
Abstract		The crystal structure of porcine cathepsin H in complex with recombinant human stefin A reveals the exopeptidase - inhibitor interaction. The Nterminal of stefin A cannot bind into the active site of cathepsin H with the same geometry as the N-terminal of stefin B in the complex with papain due to steric hindrance. It makes a beta turn and points with the Nterminal residue away from the active site cleft. C-terminal part of minichain of cathepsin H and a short insertion loop Lys155A-Asp155D are thereby displaced, their geometry appears to be disordered.
Descriptors		CATHEPSINS CYSTEINE PROTEINASE INHIBITORS RECOMBINANT PROTEINS PROTEIN STRUCTURE, TERTIARY X-RAY DIFFRACTION CRYSTALLIZATION