Author/Editor		Plevova, Pavlina
Title		Radiotherapy- and chemotherapy-induced normal tissue damage: the role of cytokines and adhesion molecules
Translated title		Poškodbe normalnega tkiva zaradi radioterapije in kemoterapije: vloga citokinov in adhezijskih molekul
Type		članek
Source		Radiol Oncol
Vol. and No.		Letnik 36, št. 2
Publication year		2002
Volume		str. 109-19
Language		eng
Abstract		Background. lonising radiation and cytostatic agents used in cancer therapy exert damaging effects on normal tissues and induce a complex response at the cellular and molecular levels. Cytokines and adhesion molecules are involved in this response. Methods. Published data on the given topic have been reviewed. Results and conclusions. Various cytokines and adhesion molecules, including tumor necrosis factor a, interleukins-1,-2,-4, and -6, interferon gamma, granulocyte macrophage- and macrophage- colony stimulating factors, transforming growth factor beta, platelet-derived growth factor, insulin-like growth factor 1, fibroblast and epidermal growth factors, platelet-activating factor, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, E- and P-selectins are involved in the response of normal tissues to ionizing radiation- and chemotherapy-induced normal tissues damage and are co-responsible for some side effects of these treatment modalities, including fever, anorexia and fatigue, suppression of hematopoiesis, both acute and late local tissue response.
Summary		Ozadje. Ionizirajoče sevanje in citostatiki, ki jih uporabljamo za zdravljenje raka, poškodujejo normalno tkivo in sprožijo celovit odgovor tako na celularni kot molekularni ravni, vanj pa so vpleteni tudi citokini in adhezijske molekule. Metode. Zbrali in pregledali smo že objavljene podatke. Rezultai in zaključki. Različni citokini in adhezjske molekule, kot so nekrotizirajoči faktor alfa interleukini 1, 2, 4 in 6, intereferon gama, granulocite in makrofage stimulirajoči faktor, transformirajoči rastni faktor beta, faktor aktiviranja krvnih ploščic, intercelična adhezijka molekula 1, vaskularno-celična adhezijska molekula- 1, in selektini E in P so vpleteni v odgovor normalnega tkiva na zdravljenje z ionozirajočim sevanjem in kemoterapijo in so odgovorni za poškodbe tkiva zaradi zdravljenja ter nezaželenih učinkov teh načinov zdravljenja, na primer vročine, anoreksije, utrujenosti, zaviranja hematopoeze ter akutnega in poznega lokalnega odziva na zdravljenje.
Descriptors		CYTOKINES CELL ADHESION MOLECULES ANTINEOPLASTIC AGENTS