Author/Editor		Abdu, Tarig AM; Elhadd, Tarik; Pfeifer, Marija; Clayton, Richard N
Title		Endothelial dysfunction in endocrine disease
Type		članek
Source		Trends Endocrin Met
Vol. and No.		Letnik 12, št. 6
Publication year		2001
Volume		str. 257-65
Language		eng
Abstract		In addition to diabetes mellitus and obesity, acromegaly, Cushing's syndrome, hypopituitarism, hypo- and hyperthyroidism, hyperparathyroidism and polycystic ovary syndrome are associated with either increased mortality from, or increased prevalence of, cardiovascular disease (CVD). Recently, endothelial dysfunction has been identified as an early marker of CVD and has been shown to predict future coronary artery disease, before atherosclerotic changes appear in arteries. Thus, measurement of endothelial function might identify at-risk individuals early and be a useful means of assessing response to treatment aimed at reducing long-term morbidity and/or mortality from CVD. Such studies are being undertaken in hypopituitarism and other endocrinopathies, and are reviewed herein. Endothelial function in large vessels can be measured noninvasively by ultrasound measurement of flowmediated endothelium-dependent dilation (FMD/. Serum markers of endothelial function, such as von Willebrand's factor, thrombomodulin, Eselectin and intercellular adhesion molecule 1, could be increased and be useful for evaluation of treatment, because they correlate inversely with FMD.
Descriptors		ATHEROSCLEROSIS ENDOTHELIUM, VASCULAR ENDOCRINE DISEASES PERIPHERAL VASCULAR DISEASES VASODILATION DIABETES MELLITUS OBESITY INSULIN RESISTANCE CELL ADHESION MOLECULES CYTOKINES POLYCYSTIC OVARY SYNDROME ACROMEGALY HYPOPITUITARISM CUSHING'S SYNDROME THYROID DISEASES