Author/Editor		Minshall, Richard D; Pavčnik, Dušan; Browne, David L; Hermsmeyer, Kent
Title		Nongenomic vasodilator action of progesterone on primate coronary arteries
Type		članek
Source		J Appl Physiol
Vol. and No.		Letnik 92
Publication year		2002
Volume		str. 701-8
Language		eng
Abstract		In the present investigation, we test the hypothesis that progesterone can rapidly relax, via a nongenomic mechanism, persistent flow occluding, agonist-activated coronary artery (CA) vasospasm, and hyperreactive vascular muscle cell (VMC) Ca2+ responses in ovariectomized rhesus monkeys. CA vasospasm, induced by injection of 100 wM serotonin and 1 wM U-46619 (5-HT+U; 1 ml/30 s), resulted in a decrease in CA diameter (phi) from 1.8 +- 0.2 to 0.3 +- 0.1 mm at the site of focal constriction. Injection of 100 ng progesterone into the CA significantly relieved the severe vasoconstriction (1.3 +- 0.2 mm) and reestablished distal flow in 3 min; the preconstriction pfi was completely restored in 8.2 +- 2.6 min (n = 6). Similarly, cell impermeant albumin-conjugated progesterone, but not albumin-conjugated 17beta-estradiol, decreased 5-HT+U stimulated VMC Ca2+ responses (250 34% of basal 30 min after stimulation) back to the prestimulation level.(113 +- 17% of basal) in 25 min (half time = 7 min). The presence of a rapid vasodilator action of progesterone in the primate CA and isolated VMC suggests its benefits in hormone replacement therapy may also include nongenomic vascular relaxant actions.
Descriptors		CORONARY VESSELS PROGESTERONE VASODILATION CALCIUM CORONARY VASOSPASM DRUG COMBINATIONS ESTRADIOL INJECTIONS, INTRA-ARTERIAL MUSCLE, SMOOTH, VASCULAR OVARIECTOMY SEROTONIN SERUM ALBUMIN, BOVINE VASOCONSTRICTION MACACA MULATTA