Author/Editor | Binkert, Christoph A; Andrews, Robert T; Pavčnik, Dušan; Uchida, Barry; Loriaux, Marc M; Toyota, Naoyuki; Roesch, Josef | |
Title | Lack of suitability of the rabbit model for particulare uterine artery embolization | |
Type | članek | |
Source | J Vasc Interv Radiol | |
Vol. and No. | Letnik 13, št. 6 | |
Publication year | 2002 | |
Volume | str. 609-12 | |
Language | eng | |
Abstract | Purpose: The goal of this study was to evaluate the rabbit model for studies of particulate uterine artery embolization (UAE). Rabbits were chosen because it was believed that their year-round breeding time and short duration of pregnancy would be useful in studies of fertility and pregnancy after UAE. Materials and methods: Bilateral UAE was performed in 12 adult female New Zealand White rabbits weighing 4-5.2 kg. All animals were proven to be breeders before treatment. Each uterine artery was embolized to stasis with use of 180-300-micro m polyvinyl alcohol (PVA) particles (n = 9 animals), 500-710-micro m PVA particles (n = 1), or tris-acryl 500-700-micro m gelatin microspheres (n = 2). Result: Two rabbits died 7 days after embolization and the other 10 rabbits had to be killed because of malaise and weight loss 4-8 d alfter embolization. In all animals, necropsy demonstrated extensive uterine necrosis sparing only the tip of the uterine horn. Conclusion: Rabbits are an unsuitable model for studies of UAE with the embolic agents in clinical use. | |
Descriptors | UTERINE NEOPLASMS EMBOLIZATION, THERAPEUTIC LEIOMYOMA POLYVINYL CHLORIDE RABBITS DISEASE MODELS, ANIMAL AORTOGRAPHY AUTOPSY |