| Author/Editor | Poredoš, Pavel | |
| Title | Motnje v delovanju endotelija in ateroskleroza | |
| Translated title | Endothelial dysfunction and atherosclerosis | |
| Type | članek | |
| Source | Krka Med Farm | |
| Vol. and No. | Letnik 23, št. 33 | |
| Publication year | 2002 | |
| Volume | str. 9-18 | |
| Language | slo | |
| Abstract | Healthy endothelium plays a central role in cardiovascular control. Therefore, endothelial dysfunction (ED), which is characterized by an imbalance between relaxing and contracting factors, procoagulant and anticoagulant substances, and between proinflammatory and antiinflammatory mediators, may play a particularly significant role in the pathogenesis of atherosclerosis. Endothelial dysfunction is ciosely related to different risk factors of atherosclerosis, to their intensity and their duration. The involvement o f risk factors in ED is also supported by results of intervention studies that showed regression of ED with treatment o f risk factors. The common denominator whereby different risk factors cause ED is most probably increased oxidative stress and/or inflammation. Endothelial dysfunction promotes atherosclerosis and probably plays an important role in the development o f thrombotic complications in the late stages of the disease. As ED is a key underlying factor in the atherosclerotic process, markers of endothelial abnormalities have been sought. Detection of ED is based on tests of endothelium dependent vasomotion (dilation capability of peripheral and coronary arteries) and on circulating markers of endothelial function (endothelin-1, von Willebrand factor, tissue plasminogen activator, plasminogen activator inhibitor, adhesion molecules). Using these tests it is possible to follow the dose-response of harmful effects of risk factors, and the effects of preventive procedures on vessel wall function. | |
| Descriptors | ENDOTHELIUM, VASCULAR ATHEROSCLEROSIS NITRIC OXIDE VASCULAR CELL ADHESION MOLECULE-1 MONOCYTE CHEMOATTRACTANT PROTEIN-1 C-REACTIVE PROTEIN INTERLEUKIN-6 P-SELECTIN ENDOTHELIN-1 VON WILLEBRAND FACTOR PLASMINOGEN ACTIVATOR INHIBITOR 1 INTERCELLULAR ADHESION MOLECULE-1 |