| Author/Editor | Drobnič, Matej; Dobnikar, Uroš | |
| Title | Vpliv ogrevanja hrbtenične regije na drgetanje pri zmerno podhlajenem človeku | |
| Type | monografija | |
| Place | Ljubljana | |
| Publisher | Medicinska fakulteta | |
| Publication year | 1996 | |
| Volume | str. 31 | |
| Language | slo | |
| Abstract | Regulation of body temperature is achieved by central processing of thermoafferent information emanating from peripheral, central and core temperature sensors, and by effector responses initiated by hypothalamic and extrahypothalamic thermoregulatory centres. The present study examined the thermosensitivity by the spinal cord and if s contribution as an extrahypothalamic thermoregulatory centre in the regulation of the shivering response. A non-invasive method for transcutaneous heating of spine was developed. Nine male subjects were immersed to the neck in a stirred bath of water maintained at 20 degrees C. Once esophageal temperature decreased by 1 degrees C from the pre-immersion value, a rubber tube attached to their spine was perfused with 50 degrees C water for 15 minutes. Results revealed that warm stimulation of the spine, which increased skin temperature (Tback from 25.1 +- 0.8 degrees C to 41.7 +- 1.6 degrees C, significantly decreased (p < 0.05) oxygen uptake, indicative of shivering thermogenesis. The decrease of oxygen uptake persisted despite a continued decline in esophageal temperature during the warm stimulation of the spine: We concluded that selective heating of spine significantly inhibits shivering during mild hypothermia. Whether this inhibition is attributable to stimulation of spinal warm temperature sensors or thermosensitive interneurons, or whether it suppressed the peripheral drive for thermogenesis being conveyed via ascending spinal pathways cannot be discerned from this study. The possibility also exists that during warm stimulation of the spine, the hypothalamus was also being heated, which could suppress shivering. Further studies will reveal the exact mechanism of inhibition of shivering during warm stimulation of the spine. (Abstract truncated at 2000 characters) | |
| Descriptors | IMMERSION REWARMING SPINAL CORD BODY TEMPERATURE REGULATION SHIVERING HEART RATE OXYGEN CONSUMPTION SKIN TEMPERATURE |