Author/Editor		Salobir, Boštjan; Preželj, Janez; Kocijančič, Andreja; Meden-Vrtovec, Helena
Title		Basal glucose level as an independent predictor of fertilization rate in patients without polycystic ovary syndrome included in an in-vitro fertilization program
Type		članek
Source		Wien Klin Wochenschr
Vol. and No.		Letnik 114, št. 12
Publication year		2002
Volume		str. 454-7
Language		eng
Abstract		Insulin resistance is a common characteristic of women with polycystic ovary syndrome (PCOS) who are known to differ in their in-vitro fertilization outcomes compared to non-PCOS patients. As insulin resislance can be found in a considerable proportion of normal individuals, we assessed its contribution to ovarian responsiveness and fertilization rate. 26 non-PCOS pa bents undergoing IVF for the first time were investigated. Insulin resistance was evaluated by using a euglycemic hyperinsulinemic clamp technique. According to multiple regression analysis insulin sensitivity, expressed as insulin stimulated glucose disposal rate, during euglycemic clamp (r =-0.81, p < 0.05 and r = -0.89; p < 0.01) and basal estradiol level (r=-0.54; p<0.05 and r=-0.56; p < 0.05) appeared significant negative predictors of the number of fertilized oocytes and embryos, respectively. Furthermore, basal glucose level appeared independently as a significant positive predictor of the number of fertilized oocytes and the number of embryos. (r=0.90; p < 0.01 and r = 0.96; p < 0.01 respectively). We conclude that blood glucose concentration and insulin resistance respectively are independent predictors of IVF outcome.
Descriptors		FERTILIZATION IN VITRO INSULIN RESISTANCE BLOOD GLUCOSE ESTRADIOL INSULIN FSH GLUCOSE CLAMP TECHNIQUE ANDROSTENEDIONE DEHYDROEPIANDROSTERONE SULFATE LH