Author/Editor		Erman, Andreja
Title		Sečni mehur miši kot model postnatalne rasti in obnove urotelija in vivo
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		2002
Volume		str. 109
Language		slo
Abstract		The urinary bladder urothelium is a highly specialized tissue, which acts as an effective blood - urine permeability barrier. The rate of turnover in the normal urothelium is very low and mitotic figures are seldom seen. Its high capacity for rapid regeneration after induced or developmentally conditioned damage has been well known for many years. A damaged urothelium is quickly re-epithelialized by high proliferation activity. On the day of birth, the architecture of the mouse urinary bladder urothelium is disrupted due to intense desquamation at the end of embryonic development. Because of the urgent and intense restoration process which follows the acute damage, mouse urothelium in the early postnatal period is an appropriate tissue for studying terminal cell differentiation and the re-building of the three layered epithelium. Basic developmental processes such as cell proliferation, differentiation and cell death were therefore studied at different postnatal days of young mice from the day of birth until the 14th postnatal day, and in adult mice. Temporal and spatial regeneration of the mouse urothelium was analyzed by light and electron microscopy using morphological, imunohistochemical and imunocytochemical methods. We envisaged two hypothetical models of the incidence of proliferation and cell death during the postnatal development of the urothelium. In accordance with the first hypothesis, we assumed the successive appearance of proliferation and cell death as in the case of urothelial renewal after chemically induced injuries. In contrast, the second hypothesis was based on the simultaneous appearance of both processes as is known during the embryonic development of the urothelium. (Abstract truncated at 2000 characters).
Descriptors		BLADDER UROTHELIUM CELL DIVISION CELL DIFFERENTIATION PLOIDIES MICE MICROSCOPY, ELECTRON APOPTOSIS IMMUNOHISTOCHEMISTRY PROLIFERATING CELL NUCLEAR ANTIGEN KI-67 ANTIGEN TUBULIN KERATIN CHROMATIN MEMBRANE PROTEINS