Author/Editor		Kolarz, G; Hermann, J; Krajnc, I; Palkonyai, E; Scherak, O; Schoedl, C; Singer, F; Temesvari, P; Wagner, E; Wottawa, A
Title		Funktionelle Kapazitaet und Cartilage Oligomeric Matrix Protein (COMP) im Serum bei Patienten mit Alterspolyarthritis
Translated title		Functional capacity and cartilage oligomeric matrix protein (COMP) in the serum of patients with late onset rheumatoid arthritis
Type		članek
Source		Z Rheumatol
Vol. and No.		Letnik 61, št. 4
Publication year		2002
Volume		str. 435-9
Language		ger
Abstract		Objective To compare late onset with adult onset rheumatoid arthritis. Methods Fifty-eight patients with late onset rheumatoid arthritis (LORA) were compared to 117 patients with adult onset rheumatoid arthritis (AORA) with respect to clinical and functional para meters. Furthermore, in 104 patients serum cartilage oligomeric matrix protein (COMP) was measured. Results were compared by means of ANOVA and possible influences of age, gender and clinical parameters were evaluated by Spearman rank correlation. Results Except a different distribution in gender (40% males in the LORA group) and a higher ESR, no differences could be found with respect to clinical parameters. However, a-significandy higher HAQ score and significantly higher serum-COMP levels could be shown in the LORA group. HAQ scores correlated not only with disease activity parameters (C-reactive protein, disease activity score) but also with the age. Serum-COMP levels did show a correlation with the age as well, but not with disease activity. Conclusion It is concluded that the higher serum-COMP levels in late onset rheumatoid arthritis could be due to concomitant osteoarthritic processes in larger joints, which are not symptomatic. The age dependence of the HAQ score is only weak, but may be the reason why patients with LORA show a worse functional capacity compared to patients with adult onset rheumatoid arthritis.
Descriptors		ARTHRITIS, RHEUMATOID CARTILAGE ADULT AGE FACTORS SEX FACTORS IGM IGG IGA