Author/Editor		Fister, Petja; Svetec, Matej
Title		Vpliv dražljajev v tarčnem tkivu na dopaminergične nevrone substance Nigre pri podgani
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		2001
Volume		str. 45
Language		slo
Abstract		BACKGROUND. Contemporary medicine has no effective means for treatment of neurodegenerative diseases and other central nervous system disorders. The latest experimental treatment options for these conditions involve invasive procedures in the central nervous system, with accompanying mechanical injury, inflammatory response, excitotoxic secondary tissue damage and activation of trophic factor synthesis and release. Influences of these processes on the central neurons have not been sufficiently explored. Success of novel invasive treatment options will largely depend on understanding and control of the effects of mechanical and excitotoxic injury, inflammation and increased availability of trophic support to the central neurons. AIM The goal of this short-term in vivo study on the rat nigrostriatal dopaminergic (Da) system was to determine and quantify the effects of (1) a mechanical injury, (2) proinflammatory factors, (3) an excitotoxic injury and (4) an injection of a Da trophic factor, glial cell line derived neurotrofic factor, GDNF. In order to control for possible direct lethal effects of the above stimuli, an additional treatment group received an injection of (5) 6-hydroxydopamine (6-OHDA), a toxin which selectively kills Da neurons. We aimed to determine how the listed stimuli affect the number of Da neurons of the substantia nigra (SN), their cell size and the innervation density of their target region, the striatum. We wanted to see if the effects of the employed stimuli differ depending on the site of their injection into the nigrostriatal system. Finally, we also performed the correlation analysis of the stimulatory effects of the most potent stimuli on Da neurons and the inflammation they caused in the parenchyma. (Abstract truncated at 2000 characters).
Descriptors		SUBSTANTIA NIGRA NEURONS OXIDOPAMINE CORPUS STRIATUM QUINOLINIC ACID RATS, WISTAR CELL COUNT LIPOPOLYSACCHARIDES INTERLEUKIN-1 IMMUNOHISTOCHEMISTRY NEUROGLIA