Author/Editor     Jan, Janja
Title     Biokoncentracija lipofilnih organoklornih onesnaževalcev v zobnih tkivih ovac in ljudi
Translated title     Bioconcentration of lipophilic organochlorine pollutants in ovine and human dental tissues
Type     monografija
Place     Ljubljana
Publisher     Medicinska fakulteta
Publication year     2002
Volume     str. 97
Language     slo
Abstract     Polychlorinated biphenyls (PCBs) and organochlorine pesticides are lipophilic, highly persistent and ubiquitous environmental pollutants. Since exposure to organochlorine compounds (OCs) may cause developmental dental defects, their bioconcentration in dental tissues must be investigated. Lipid content is thought to be the main factor influencing the bioconcentration of lipophilic organochlorines in various tissues. Hard dental tissues have a low lipid content. The aims of the study were: to determine the bioconcentration of various lipophilic OCs in the dental tissues of a population with a high prevalence of developmental enamel defects; to identify the factors affecting the bioconcentration of these pollutants in dental tissues; to explore possible differences in the bioconcentration of OCs between deciduous and permanent teeth; to evaluate the impact of the developmental stage of the tooth at the time of exposure on the bioconcentration of the pollutants; to establish if OCs are sorbed to hydroxyapatite and proteins in hard dental tissues; and to determine if dental tissues could be used as biomarkers of exposure to OCs. OCs levels were determined in dental tissues of the local population in a polluted (Bela krajina) and an unpolluted area (Bršljin). For better understanding of the results, two actively lactating sheep were administered a single dose of PCB congeners (tetrachlorobiphenyls IUPAC Nos. 54 and 80, and hexachlorobiphenyls IUPAC Nos. 155 and 169) and organochlorine pesticides Šhexachlorobenzene (HCB) and dichlorodiphenyldichloroethene (DDE)Ć. The sheep were sacrificed two months after exposure, and the lambs at the age of three months. OCs levels in dental and other tissues were determined by high-resolution gas chromatography with electron-capture detection. Synthetic hydroxyapatite and gelatine were used as stationary phases for adsorption chromatography. (Abstract truncated at 2000 characters).
Descriptors     PESTICIDE RESIDUES
POLYCHLORINATED BIPHENYLS
INSECTICIDES, ORGANOCHLORINE
TOOTH
CHROMATOGRAPHY, HIGH PRESSURE LIQUID
ADIPOSE TISSUE
BONE AND BONES
LIVER
BRAIN
ENVIRONMENTAL POLLUTANTS
SHEEP