Author/Editor		Brvar, Miran; Grenc, Damjan; Možina, Martin; Bunc, Matjaž
Title		Zastrupitve z gama-hidroksibutiratom, gama-butirolaktonom in 1,4-butandiolom
Translated title		Poisoning with gamma-hydroxybutyrate, gamma-butyrolactone and 1,4-butandiol
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 71, št. 9
Publication year		2002
Volume		str. 535-7
Language		slo
Abstract		Background. Gamma-hydroxybutyrate (GHB) is a popular recreational drug. GHB overdose typically presents with decreased level of consciousness, miosis, bradycardia, respiratory depression and death. Typically, combativeness, confusion and vomiting occur once the patient begins to recover. Gamma-butyrolactone (GBL) and 1.4-butandiol (1.4-BD) are the prodrugs of GHB and have similar clinical presentation. We present the case of GHB poisoning in Ljubjana. Conclusions. Physicians should suspect GHB poisoning in young ravers who present with CNS depression. Treatment is symptomatic. There is no specific antidote. Gastric lavage is not beneficial but activated charcoal is recommended.
Summary		Izhodišča. Gama-hidroksibutirat (GHB) je vse pogostejša rekreativna droga. Znaki zastrupitve z GHB so motnja zavesti, ozki zenici, počasen pulz, počasno in plitvo dihanje ter smrt. Med prebujanjem so bolniki pogosto agresivni, zmedeni in bruhajo. Gama-butirolakton (GBL) in 1,4-butandiol (1, 4-BD) sta naravna prekurzorja GHB, zato je klinična slika zastrupitve podobna zastrupitvi z GHB. V prispevku je opisan primer zastrupitve z GHB v Ljubljani. Zaključki. Na GHB moramo pomisliti pri mladem bolniku z moteno zavestjo, ki so ga pripeljali iz nočnega lokala oziroma rejva. Zdravljenje je simptomatično. Specifičnega antidota ni. Lavaža želodca ni učinkovita, priporočamo pa aktivno oglje.
Descriptors		HYDROXYBUTYRATES 4-BUTYROLACTONE BUTANEDIOLS ADOLESCENCE