Author/Editor		Kern, Izidor
Title		Diagnostika intersticijskih pljučnih bolezni iz bronhoskopsko odvzetih koščkov tkiva
Translated title		Bronchoscopic tissue sampling for the diagnosis of interstitial lung diseases
Type		članek
Source		Endoskopska revija
Vol. and No.		Letnik 7, št. 18
Publication year		2002
Volume		str. 40-5
Language		slo
Abstract		Background. Bronchoscopic lung biopsy (BLB) is a method used for histopathological diagnosis of lung parenchymal lesions, occurring also in interstitial lung diseases. The objective of this study was to determine the diagnostic yield of BLB at this institution relative to the results published in the literature. Material and methods. All BPBs performed in 1990 and in the past 6 months were included in the analysis. According to the original histopathological diagnosis, the specimens were assigned to the following four groups: nonrepresentative/nondiagnostic, nonspecific, possibly specific and specific. Our previous results and the results from other institutions were categorized by the same method. Results. The proportion of nonrepresentative/nondiagnostic specimens was 11%. It was lower than our previous results and lower than the findings published by other authors. Approximately one third of histopathological changes were diagnosed as nonspecific. The proportion of possibly specific results was higher than the percentage reported in the literature. The proportion of specific diagnoses did not differ significantly from the published data. The diagnostic yield, i.e. the sum of proportions of specific and possibly specific diagnoses, was 55%; it was higher than the yield documented at this institution in the previous years and the percentage publiished in the literature. The diagnosed infections and neoplasms that accounted for 11% to 53% of specific diagnoses contributed considerably to the total diagnostic yield of BLB. Sarcoidosis was the most common entity among specific diagnoses; other conditions were diagnosed rarely. Conclusions. BLB is a useful technique used for diagnosing sarcoidosis and some rare interstitial lung diseases. It is valuable in excluding other diseases with characteristic histopathological changes, such as infections and neoplasms, which are not classified as interstitial lung diseases. (Abstract truncated at 2000 characters).
Summary		Bronhoskopska pljučna biopsija (BPB) je diagnostična metoda za histopatološko opredeljevanje sprememb pljučnega parenhima, med katere sodijo tudi intersticijske pljučne bolezni. Zanimala me je diagnostična vrednost preiskave in primerjava z izkušnjami drugih. Material in metode. V analizo sem zajel vse BPB v naši ustanovi v letih 1999 in 2001-02. Originalne histopatološke diagnoze sem klasificiral v štiri skupine: nereprezentativni/nediagnostični vzorec, nespecifična, potencialno specifična in specifična diagnoza. Za primerjavo sem vzel objavljene domače in tuje podatke, ki sem jih lahko obdelal po isti metodi. Rezultati. Delež nereprezentativnih/nediagnostičnih vzorcev je bil 11% in je bil manjši, kot je bil leta 1987, in manjši od objavljenih podatkov tujih avtorjev. Približno ena tretjina histopatoloških sprememb je bila nespecifičnih. Delež potencialno specifičnih diagnoz je bil večji v primerjavi z objavljenimi. Delež specifičnih diagnoz se med nami in objavljenimi podatki ni bistveno razlikoval. Diagnostična vrednost, ki je seštevek deleža specifičnih in potencialno specifičnih diagnoz, je bila 55% in je bila večja kot v preteklosti ter večja od drugih avtorjev. Pomemben prispevek k uspešnosti BPB so predstavljale diagnosticirane okužbe in neoplazme (skupaj od 11% do 53%). Med specifičnimi diagnozami je bila najpogostejša sarkoidoza, ostale bolezni so bile redke. Zaključki. BPB je uspešna za potrjevanje sarkoidoze in redkih drugih intersticijskih pljučnih bolezni. Njena vrednost je tudi v izključevanju drugih bolezni s specifičnimi histopatološkimi spremembami (neoplazme, okužbe), ki pa niso intersticijske pljučne bolezni. Na diagnostično vrednost pomembno vplivajo dobre klinične in rentgenološke informacije.
Descriptors		LUNG DISEASES, INTERSTITIAL BRONCHOSCOPY BIOPSY