Author/Editor		Rajčević, Uroš
Title		Ugotavljanje ravni izražanja onkogenov pri raku želodca s fluorescenčnim označevanjem in sočasnim pomnoževanjem genskih prepisov
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		2002
Volume		str. 75
Language		slo
Abstract		Adenocarcinoma of the stomach can be devided into two clinicopathological entities based on histology: "epidemic", intestinal, or well-differentiated carcinoma and diffuse or poorly differentiated carcinoma. While intestinal-type lesions follow a series of well characterized stages progressing from chronic gastritis in a similar pattern as described in colorectal carcinogenesis, poorly differentiated gastric cancer lack well- recognized precursor changes seen in intestinal-type lesions. Factors leading to the development of diffuse type of stomach cancer are less clear. The transformation of normal gastric epithelial cells into a cancer is a multi-step process associated with the progressive accumulation of abnormalties in DNArepair genes, tumor supressor genes and oncogenes such as genes encoding cellular growth factors, surface receptors and celular adhesion molecules. Although there is a lot of confussion concerning the actual sequence of events that gives rise to gastric cancer, there's a consensus that genetic instability, inactivation of tumor supressor genes and overexpression of telomerase appear to be involved in the earfy stages of gastric carcinogenesis, whereas activation of oncogenes, expression of growth factors, cytokines and angiogenic factors promote the later stages of tumor progression and invasion. Cellular oncogenes may be defined as genes which, under certain conditions, are capable of inducing neoplastic transformation of cells. Cellular oncogenes arise by the modification through mutation, or change in the control of expression of a normal gene, referred to as "proto-oncogene". Beside oncogenes deriving from cellular, oncogenes are being carried also by genomes of some oncogenic viruses. (Abstract truncated at 2000 characters).
Descriptors		STOMACH NEOPLASMS ADENOCARCINOMA ONCOGENE PROTEINS ALLELES GENE EXPRESSION REGULATION, NEOPLASTIC CYCLINS POLYMERASE CHAIN REACTION FLUORESCENCE EPIDERMAL GROWTH FACTOR RECEPTOR PROTEIN-TYROSINE KINASE FIBROBLAST GROWTH FACTOR BASE SEQUENCE ELECTROPHORESIS, CAPILLARY CHROMATOGRAPHY, HIGH PRESSURE LIQUID HEPATOCYTE GROWTH FACTOR PROTO-ONCOGENE PROTEINS