Author/Editor		Velenšek-Prestor, V; Jazbec, J
Title		Preživetje otrok in mladostnikov s solidnimi tumorji v Sloveniji v obdobju 1990-200
Translated title		Survival of children and adolescents with solid tumours in Slovenia in the period 1990-200
Type		članek
Source		Slov Pediatr
Vol. and No.		Letnik 9, št. 2-3
Publication year		2002
Volume		str. 94-9
Language		slo
Abstract		A retrospective clinical analysis was performed to evaluate the outcome in 184 children with different solid tumours and Hodgkin lymphoma treated at the Department of Paediatric Oncology and Haematology in Ljubljana between 1990 - 2000. Thirty-seven of these patients (pts) had Wilms tumour, 31 pts had neuroblastoma, 25 pts had rhabdomyosarcoma (RMS), 18 pts had Ewing sarcoma /PNETof bone, 16 pts had osteosarcoma and 57 pts had Hodgkin disease. They were 17 days to 18 years old at diagnosis. Patients were treated according to the diagnosis and stage of the disease with chemotherapy, surgery and radiotherapy. Nine patients also underwent bone marrow transplantation. The observation period was from the time of diagnosis until the last follow-up or until death from any cause. The follow-up time was 0.25-12 years. Event-free survival rate (EFS) and the overall survival rate (OS) were estimated using the Kaplan-Maier method. The results of Kaplan-Maier analysis were as follows: the 2-year OS for the entire group of pts with Wilms tumour was 84 % (EFS 80 %), in stage 1 91 %, in stage 2 80 %, in stage 3 60 %, in stage 5 66 %. The 2-year OS for the entire group of pts with neuroblastoma was 61 % (EFS 54 %), for stage 1 and 2 100 %, stage 3 50 %, stage 4 21 %. The 2-year OS for the entire group of pts with RMS was 75 % (EFS 64 %), for stage 1 90 %, for stage 2 85 %, for stage 3 50 %, for stage 4 40 %. The 2year OS for all pts with Ewing sarcoma /PNET of bone was 64 % (EFS 45 %), for pts with PNET 67 %, for pts with Ewing sarcoma 27 %. The 2-year OS for all pts with osteosarcoma was 81 % (EFS 53 %). The 2-year OS for all pts with Hodgkin disease was 96 % (EFS 93 %), the 2-year OS in stage lis 100 %, in stage 2 96 %, in stage 3 93 %, in stage 4 53 %. A high overall survival outcome was obtained for patients with Hodgkin disease and Wilms tumour. (Abstract truncated at 2000 characters).
Summary		V retrospektivni raziskavi smo analizirali preživetje 184 otrok in mladostnikov z različnimi solidnimi tumorji in Hodgkinovim limfomom, ki so se zdravili na oddelku za onkologijo in hematologijo Pediatrične klinike v Ljubljani v obdobju 1990 - 2000. V raziskavo smo vključili bolnike z Wilmsovim tumorjem, bolnike z nevroblastomom, bolnike z rabdomiosarkomom, bolnikov z Ewingovim sarkomom in s primitivnim nevroektodermalnim tumorjem-PNET, bolnike z osteogenim sarkomom in bolnike s Hodgkinovim limfomom. V času diagnoze so bili stari 17 dni do 18 let. Bolnike smo zdravili glede na diagnozo in stadij bolezni s kemoterapijo, operacijo in obsevanjem, devetim bolnikom smo presadili kostni mozeg. Bolnike smo opazovali od postavitve diagnoze do zadnje kontrole oziroma smrti. Čas opazovanja vseh bolnikov je bil od 0,25 let do 12 let. Za oceno dobe preživetja in obdobja brez bolezni (OBB) smo uporabili Kaplan - Maierjevo metodo. Rezultati Kaplan - Maierjeve analize preživetja so pokazali, da je bilo 2-letno preživetje za celotno skupino bolnikov z Wilmsovim tumorjem 84 % (OBB 80 %), 91 % za stadij 1, 80 % za stadij 2, 60 % za stadij 3, 66 % za stadij 4. Za bolnike z nevroblastomom je bilo 2-letno pre*ivetje 61 % (OBB 54 %), 100 % za stadij 1, 2 in 4S, 50 % za stadij 3, 21 % za stadij 4. 2letno preživetje za celotno skupino bolnikov z rabdomiosarkomom je bilo 75 % (OBB 64 %), 90 % za stadij 1, 85 % za stadij 2, 50 % za stadij 3, 40 % za stadij 4. Za celotno skupino bolnikov z Ewingovim sarkomom in PNET je bilo 2-letno preživetje 64 % (OBB 45 %), za bolnike s histološko diagnozo PNET 67 %, za bolnike z diagnozo Ewingov sarkom pa 27 %. (Izvleček prekinjen pri 2000 znakih).
Descriptors		NEOPLASMS SURVIVAL ANALYSIS CHILD NEPHROBLASTOMA RHABDOMYOSARCOMA SARCOMA, EWING'S HODGKIN'S DISEASE