Author/Editor		Hočevar-Boltežar, Irena; Žargi, Miha
Title		Laryngeal papillomatosis
Translated title		Papilomatoza grla
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 71, št. Suppl 3
Publication year		2002
Volume		str. III-73-6
Language		eng
Abstract		Background. Laryngeal papillomatosis is a rare disease of the upper respiratory tract, which may have a dramatic course. The results of many studies have proved a viral etiology, but the precise mode of the virus transmission remains indistinct. Surgery is the most successful mode of treatment. Adjuvant therapy is indicated only in an aggressive form of the disease. Patients. In the last 23 years, 136 patients have been treated for laryngeal papillomatosis at the Department of Otorhinolaryngology and Cervicofacial Surgery in Ljubljana. All patients were treated surgically; since 1995, CO2 laser has been used. Eighteen patients with aggressive disease received adjuvant therapy. Only in 2.2% of patients was tracheotomy necessary. In 9.6% of patients, laryngeal scarring occurred as a result of repeated surgical procedures. In 2.2%, malignant alteration of laryngeal papillomatosis developed. Conclusions. The outcome of treatment of laryngeal papillomatosis in Ljubljana is comparable to the results of other centres. As carcinoma may develop, although very rarely, more than 10 years after the onset of laryngeal papillomatosis, all patients must be followed carefully.
Summary		Izhodišča. Papilomatoza grla je relativno redka bolezen zgornje dihalne poti, katere klinični potek pa je lahko za bolnika usoden. številne raziskave so potrdile virusno etiologijo bolezni, ni pa še povsem pojasnjen prenos povzročitelja. Doslej najbolj uspešno zdravljenje je kirurško , za adjuvantno zdravljenje pa se odločamo samo v primerih agresivne oblike bolezni. Prikaz bolnikov. V zadnjih 23 letih se je na Kliniki za otorinolaringologijo in cervikofacialno kirurgijo v Ljubljani zdravilo 136 bolnikov s papilomatozo grla. Vsi so bili zdravljeni kirurško, od leta 1995 dalje s pomočjo laserja CO2. 18 bolnikov z agresivno obliko bolezni smo zdravili še z adjuvantno terapijo. Le pri 2.2% bolnikov je bila potrebna traheotomija zaradi ogrožene dihalne poti. Pri 9,6% bolnikov so nastale brazgotinske spremembe v grlu kot posledica ponavljajočih kirurških posegov. Pri 2,2% bolnikov se je v grlu nekaj let po vzniku papilomov pojavil karcinom. Zaključki. Uspehi zdravljenja bolnikov s papilomatozo grla v Ljubljani so primerljivi rezultatom drugih svetovnih centrov. Zaradi možnega-čeprav redkega-pojava ploščatoceličnega karcinoma v grlu tudi več 10 let po pojavu papilomatoze grla, je nujno stalno dolgoletno spremljanje bolnikov.
Descriptors		LARYNGEAL NEOPLASMS PAPILLOMA TRACHEOTOMY INTERFERON-ALPHA ACYCLOVIR LASER COAGULATION