Author/Editor		Brunner, J; Stalla, GK; Stalla, J; Uhr, M; Grabner, A; Wetter, TC; Bronisch, T
Title		Decreased corticotropin-releasing hormone (CRH) concentrations in the cerebrospinal fluid of eucortisolemic suicide attempters
Type		članek
Source		In: Grad-Tekavčič O, editor. Suicide risk and protective factors in the new millennium. Ljubljana: Cankarjev dom,
Publication year		2001
Volume		str. 131-5
Language		eng
Abstract		Controversial results have emerged from the determination of CRH concentrations in the CSF of suicide attempters. We simultaneously measured CRH concentrations in the CSF and in the plasma of 41 psychiatric inpatients with different diagnoses (affective disorder, schizophrenia, personality disorders, adjustment disoder, substance abuse) and 8 neurological control subjects. The major finding was that patients who attempted suicide prior to admission had significantly lower CSF CRH concentrations than psychiatric patients without suicidal behavior. Patients with acute suicidal ideations showed a trend towards lower CSF CRH concentrations compared to the neurological control subjects. Patients with affective disorder alone as well as patients with multiple diagnoses, but not schizophrenic patients, showed significantly lower CSF CRH concentrations than neurological control subjects. Plasma CRH and plasma cortisol concentrations did not differ among diagnostic groups or between suicide attempters vs. non-attempters.
Descriptors		SUICIDE, ATTEMPTED CORTICOTROPIN-RELEASING HORMONE MENTAL DISORDERS